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Eicosanoid receptor

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Title: Eicosanoid receptor  
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Eicosanoid receptor

An eicosanoid receptor is an integral membrane protein that detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.[1]

The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:[2][3]

Contents

  • Leukotriene 1
  • Lipoxin 2
  • Oxoeicosanoid 3
  • Prostanoid 4
  • References 5
  • External links 6

Leukotriene

Leukotrienes:

The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.[4]

Lipoxin

Lipoxins:

Oxoeicosanoid

Oxoeicosanoid:[5]

Prostanoid

Prostanoids:

References

  1. ^ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). "The nuclear eicosanoid receptor,  
  2. ^ Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29.  
  3. ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). "International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors". Pharmacol. Rev. 55 (1): 195–227.  
  4. ^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72.  
  5. ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57.  

External links

  • "Leukotriene Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • "Prostanoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • Eicosanoid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)


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