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Enteroendocrine cell

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Title: Enteroendocrine cell  
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Subject: Goblet cell, G cell, Oxyphil cell (parathyroid), Alpha cell, Follicular cell
Collection: Animal Cells, Endocrine System, Secretory Cells, Stomach
Publisher: World Heritage Encyclopedia

Enteroendocrine cell

Enteroendocrine cells
Actions of the major digestive hormones secreted by enteroendocrine cells
Latin endocrinocyti gastroenteropancreatici
MeSH Enteroendocrine+cells
Code TH H3.
TH H3.
Anatomical terminology

Enteroendocrine cells are specialized endocrine cells of the gastrointestinal tract and pancreas. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.[1][2] Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body.[3][4][5] In a sense they are known to act as chemoreceptors, initiating digestive actions and detecting harmful substances and initiating protective responses.[6][7] Enteroendocrine cells are located in the stomach, in the intestine and in the pancreas.


  • Intestinal enteroendocrine cells 1
    • K cell 1.1
    • L cell 1.2
    • I cell 1.3
    • G cell 1.4
    • Enterochromaffin cell 1.5
    • N cell 1.6
    • S cell 1.7
  • Gastric enteroendocrine cells 2
  • Pancreatic enteroendocrine cells 3
  • Pathology 4
  • See also 5
  • References 6
  • External links 7

Intestinal enteroendocrine cells

Intestinal enteroendocrine cells are not clustered together but spread as single cells throughout the intestinal tract.[8]

Hormones secreted include somatostatin, motilin, cholecystokinin, neurotensin, vasoactive intestinal peptide, and enteroglucagon.[9]

K cell

K cells secrete gastric inhibitory peptide, an incretin, which also promotes triglyceride storage.[10]

L cell

L cells secrete glucagon-like peptide-1, an incretin, PYY peptide YY, oxyntomodulin and glucagon-like peptide-2. L cells are primarily found in the ileum and large intestine (colon), but some are also found in the duodenum and jejunum.[11]

I cell

I cells secrete cholecystokinin (CCK), and are located in the duodenum and jejunum. They modulate bile secretion, exocrine pancreas secretion, and satiety. [12]

G cell

Stomach enteroendocrine cells, which release gastrin, and stimulate gastric acid secretion. [13]

Enterochromaffin cell

Enterochromaffin cells are enteroendocrine and neuroendocrine cells with a close similarity to adrenomedullary chromaffin cells secreting serotonin. [14]

N cell

Located in the jejunum, N cells release neurotensin, and control smooth muscle contraction.[15]

S cell

S cells secrete secretin from the duodenum and jejunum, and stimulate exocrine pancreatic secretion. [12]

Gastric enteroendocrine cells

Gastric enteroendocrine cells are found in the gastric glands, mostly at their base. The G cells secrete gastrin, post-ganglionic fibers of the vagus nerve can release gastrin-releasing peptide during parasympathetic stimulation to stimulate secretion. Enterochromaffin-like cells are enteroendocrine and neuroendocrine cells also known for their similarity to chromaffin cells secreting histamine, which gastrin stimulates.

Other hormones produced include cholecystokinin, somatostatin, vasoactive intestinal peptide, substance P, alpha and gamma-endorphin.[9][16]

Pancreatic enteroendocrine cells

Pancreatic enteroendocrine cells are located in the islets of Langerhans and produce most importantly the hormones insulin and glucagon. The autonomous nervous system strongly regulates their secretion, with parasympathetic stimulation stimulating insulin secretion and inhibiting glucagon secretion and sympathetic stimulation having opposite effect.[17]

Other hormones produced include somatostatin, pancreatic polypeptide, amylin and ghrelin.


Rare and slow growing carcinoid and non-carcinoid tumors develop from these cells. When a tumor arises it has the capacity to secrete large volumes of hormones.[2][18]

See also


  1. ^ Rehfeld, Jens F (1998). "The New Biology of Gastrointestinal Hormones". Physiol. Rev 78: 1087–1108. 
  2. ^ a b Solcia, E; Capella, C; Buffa, R; Usellini, L; Fiocca, R; Frigerio, B; Tenti, P; Sessa, F (1981). "The diffuse endocrine-paracrine system of the gut in health and disease: ultrastructural features.". Scandinavian journal of gastroenterology. Supplement 70: 25–36.  
  3. ^ Ahlman, H; Nilsson, (2001). "The gut as the largest endocrine organ in the body." (PDF). Annals of Oncology. 12 Suppl 2 (suppl 2): S63–8.  
  4. ^ Schonhoff, SE; Giel-Moloney, M; Leiter, AB (June 2004). "Minireview: Development and differentiation of gut endocrine cells.". Endocrinology 145 (6): 2639–44.  
  5. ^ Moran, G. W.; Leslie, F. C.; Levison, S. E.; McLaughlin, J. T. (1 July 2008). "Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?". Therapeutic Advances in Gastroenterology 1 (1): 51–60.  
  6. ^ Sternini, C; Anselmi, L; Rozengurt, E (February 2008). "Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing.". Current Opinion in Endocrinology, Diabetes and Obesity 15 (1): 73–8.  
  7. ^ Sternini, C (February 2007). "Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing.". American journal of physiology. Gastrointestinal and liver physiology 292 (2): G457–61.  
  8. ^ Sternini, Catia; Anselmi, Laura; Rozengurt, Enrique (1 February 2008). "Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing". Current Opinion in Endocrinology, Diabetes and Obesity 15 (1): 73–78.  
  9. ^ a b Krause, WJ; Yamada, J; Cutts, JH (June 1985). "Quantitative distribution of enteroendocrine cells in the gastrointestinal tract of the adult opossum, Didelphis virginiana." (PDF). Journal of anatomy 140 (4): 591–605.  
  10. ^ Parker, H. E.; Habib, A.M.; Rogers, G.J.; Gribble, F.M.; Reimann, F. (2009). "Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells.". Diabetologia 52 (2): 289–298.  
  11. ^ Drucker DJ, Nauck MA (2006). "The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes" (PDF).  
  12. ^ a b Brubaker, P. (2012). "A beautiful cell (or two or three?).". Endocrinology 153 (7): 2945–8.  
  13. ^ Friis-Hansen, L (1998). "Impaired Gastric Acid Secretion in Gastrin-deficient Mice". Am J Physiol 274 (3): G561-568.  
  14. ^ Orsmbee, H.S.; Fondacaro, J. D.3919396 (1985). "Action of serotonin on the gastrointestinal tract.". Proc Soc Exp Biol Med 178 (3): 333–8.  
  15. ^ Kitabgi, P; Freychet, P (1978). "Effects of neurotensin on isolated intestinal smooth muscles.". Eur J Pharmacol 50 (4): 348-57.  
  16. ^ Zverkov, IV; Vinogradov, VA; Smagin, VG (October 1983). "Endorphin-containing cells in the gastric antral mucosa in duodenal ulcer.". Biulleten' eksperimental'noi biologii i meditsiny 96 (10): 32–4.  
  17. ^ Kiba, T (August 2004). "Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments.". Pancreas 29 (2): e51–8.  
  18. ^ Warner, RR (May 2005). "Enteroendocrine tumors other than carcinoid: a review of clinically significant advances.". Gastroenterology 128 (6): 1668–84.  

External links

  • Enteroendocrine cells at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Histology image: 11604loa – Histology Learning System at Boston University - "Endocrine System: duodenum, enteroendocrine cells"
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