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Title: Epicriptine  
Author: World Heritage Encyclopedia
Language: English
Subject: Lysergic acid diethylamide, Nafadotride, SKF-89,145, 2-OH-NPA, AS-8112
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(2R,4R,7R)-N- [(1S,2S,4R,7S)- 2-hydroxy- 7-(S)-(1-methylpropyl)- 5,8-dioxo- 4-(propan-2-yl)- 3-oxa- 6,9-diazatricyclo [,6]dodecan-4-yl]- 6-methyl- 6,11-diazatetracyclo [,7.012,16] hexadeca- 1(16),9,12,14-tetraene- 4-carboxamide
Clinical data
Pregnancy cat.
  • Contraindicated
Legal status
  • Prescription only
Routes Oral
CAS number
ATC code N04 (alpha/beta)
Synonyms beta-Dihydroergocryptine
Chemical data
Formula C32H43N5O5 
Mol. mass 577.715 g/mol

Epicriptine or beta-dihydroergocryptine is a dopamine agonist of the ergoline class. It constitutes one third of the mixture known as dihydroergocryptine, the other two thirds consisting of alpha-dihydroergocryptine. The alpha differs from the beta form only in the position of a single methyl group, which is a consequence of the biosynthesis in which the proteinogenic amino acid isoleucine is replaced by leucine.[1]


  1. ^ Steinhilber, D; Schubert-Zsilavecz, M; Roth, HJ (2005). Medizinische Chemie (in German). Stuttgart: Deutscher Apotheker Verlag. p. 142.  

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