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Epstein-Barr virus snoRNA1

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Title: Epstein-Barr virus snoRNA1  
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Subject: Epstein–Barr virus
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Epstein-Barr virus snoRNA1

Human herpesvirus 1 small nucleolar RNA
Sequence concservation of v-snoRNA1
Symbol v-snoRNA1
Rfam RF01516
Other data
RNA type snoRNA

V-snoRNA1 is a box CD-snoRNA identified in B lymphocytes infected with Epstein-Barr virus (also called human herpesvirus 4 (HHV-4)).[1] This snoRNA is the first known example of a snoRNA expressed from a viral genome.[2] It is homologous to eukaryotic snoRNAs as it contains the C and D boxes sequence motifs but lacks a terminal stem loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58. It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24 nucleotide sized RNA fragments that target the 3'UTR of viral DNA polymerase mRNA.[1]


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