World Library  
Flag as Inappropriate
Email this Article

Exchange transfusion

Article Id: WHEBN0006423871
Reproduction Date:

Title: Exchange transfusion  
Author: World Heritage Encyclopedia
Language: English
Subject: Transfusion medicine, Neonatology, Ii antigen system, Cryosupernatant, Lucio's phenomenon
Collection: Neonatology, Transfusion Medicine
Publisher: World Heritage Encyclopedia

Exchange transfusion

Exchange transfusion
ICD-9 99.01
OPS-301 code 8-801

An exchange transfusion is a medical treatment in which apheresis is used to remove one person's red blood cells or platelets and replace them with blood products. Exchange transfusion is used in the treatment of a number of diseases, including:

Partial exchange might be required for polycythemia. The technique was originally developed by Alexander Wiener, soon after he co-discovered the Rh Factor.[1]


  • Description 1
  • Risks 2
  • Recovery 3
  • See also 4
  • References 5
  • External links 6


An exchange transfusion requires that the patient's blood can be removed and replaced. In most cases, this involves placing one or more thin tubes, called catheters, into a blood vessel. The exchange transfusion is done in cycles: each one usually lasts a few minutes.

The patient’s blood is slowly withdrawn (usually about 5 to 20 mL at a time, depending on the patient’s size and the severity of illness) and a slightly larger amount of fresh, prewarmed blood or plasma flows into the patient's body. This cycle is repeated until the correct volume of blood has been replaced.

After the exchange transfusion, catheters may be left in place in case the procedure needs to be repeated.

In diseases such as sickle cell anemia, blood is removed and replaced with donor blood.

In conditions such as neonatal polycythemia, a specific amount of the child’s blood is removed and replaced with normal saline, plasma (the clear liquid portion of blood), or an albumin solution. This decreases the total number of red blood cells in the body and makes it easier for blood to flow through the body.


General risks are the same as with any transfusion. Other possible complications include:

  • Blood clots
  • Changes in blood chemistry (high or low potassium, low calcium, low glucose, change in acid-base balance in the blood )
  • Heart and lung problems
  • Infection (greatly decreased risk due to careful screening of blood)
  • Shock due to inadequate replacement of blood


The patient may need to be monitored for several days in the hospital after the transfusion, but the length of stay generally depends on the condition for which the exchange transfusion was performed.

See also


  1. ^ [1] Alexander Wiener biography
  • Exchange transfusion on MedlinePlus

External links

  • Neonatal Partial Exchange Transfusion Calculator
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.