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Fgf10

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Title: Fgf10  
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Subject: Cleft lip and palate, Fibroblast growth factor, Apical ectodermal ridge, Limb development, Limb bud, Fibroblast growth factor receptor 2, Keratinocyte growth factor
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Fgf10

Fibroblast growth factor 10
PDB rendering based on 1nun.
Available structures
PDB Ortholog search: RCSB
Identifiers
FGF10 Gene
Orthologs
SpeciesHumanMouse

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.[2]

References

Further reading

External links

  • OMIM entry on aplasia of lacrimal and salivary glands



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