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Fgf4

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Subject: Achondroplasia, Apical ectodermal ridge, Limb development, Fibroblast growth factor receptor 2
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Fgf4

Fibroblast growth factor 4
PDB rendering based on 1ijt.
Available structures
PDB Ortholog search: RCSB
Identifiers
FGF4 Gene
RNA expression pattern

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.[2]

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