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Fzd8

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Fzd8

Frizzled family receptor 8
PDB rendering based on 1ijy.
Available structures
PDB Ortholog search: RCSB
Identifiers
FZD8 Gene
RNA expression pattern

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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