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Fasiplon

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Title: Fasiplon  
Author: World Heritage Encyclopedia
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Subject: Nonbenzodiazepine, Imidazopyridine, CP-615,003, Heptobarbital, Nealbarbital
Collection: Gabaa Receptor Positive Allosteric Modulators, Imidazopyrimidines, Oxadiazoles, Sedatives
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Fasiplon

Fasiplon
Systematic (IUPAC) name
6-Ethyl-7-methoxy-5-methyl-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-imidazo[1,2-a]pyrimidine
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  N
UNII  YesY
Chemical data
Formula C13H15N5O2 
Mol. mass 273.290 g/mol
 N   

Fasiplon (RU 33203) is a nonbenzodiazepine anxiolytic drug from the imidazopyrimidine family of drugs.

Fasiplon binds strongly to benzodiazepine sites on the GABAA receptor and has similar anxiolytic effects in animals, but with less sedative or muscle relaxant action.[1] It was developed by a team at Roussel Uclaf in the 1990s[2]

References

  1. ^ Tully WR, Gardner CR, Gillespie RJ, Westwood R (July 1991). "2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors". Journal of Medicinal Chemistry 34 (7): 2060–7.  
  2. ^ US Patent 5869481 Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making
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