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Title: Fedotozine  
Author: World Heritage Encyclopedia
Language: English
Subject: Kobret, Hemorphin, Naloxonazine, Naloxol, Gemazocine
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • Non-regulated
Routes Oral
CAS number
133267-27-3 (tartrate)
ATC code None
Chemical data
Formula C22H31NO4 
Mol. mass 373.486 g/mol

Fedotozine (INN; Jo-1196) is an opioid drug of the arylacetamide series which acts as a peripherally-specific, selective κ1-opioid receptor agonist with preference for the κ1A subtype.[1] It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials,[1][2][3] but ultimately development was discontinued and it was never marketed.

See also


  1. ^ a b Delvaux M (January 2001). "Pharmacology and clinical experience with fedotozine". Expert Opinion on Investigational Drugs 10 (1): 97–110.  
  2. ^ Barber A, Gottschlich R (October 1997). "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opinion on Investigational Drugs 6 (10): 1351–68.  
  3. ^ Lembo A (2006). "Peripheral opioids for functional GI disease: a reappraisal". Digestive Diseases (Basel, Switzerland) 24 (1-2): 91–8.  

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