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Title: Flesinoxan  
Author: World Heritage Encyclopedia
Language: English
Subject: 5-HT1A receptor, S-14671, Eptapirone, Befiradol, LP-44
Collection: Alcohols, Benzamides, Benzodioxins, Organofluorides, Piperazines, Serotonin Receptor Agonists
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • Uncontrolled
Routes of
CAS Registry Number
ATC code None
PubChem CID:
Chemical data
Formula C22H26FN3O4
Molecular mass 415.458 g/mol

Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class.[1][2][3] Originally developed as a potential antihypertensive drug,[1][2][4] flesinoxan was later found to possess antidepressant and anxiolytic effects in animal tests.[5][6] As a result, it was investigated in several small human pilot studies for the treatment of major depressive disorder, and was found to have robust effectiveness and very good tolerability.[7][8] Unfortunately however, due to "management decisions", the development of flesinoxan was stopped and it was not pursued any further.[9]

In patients, flesinoxan enhances REM sleep latency, decreases body temperature, and increases ACTH, cortisol, prolactin, and growth hormone secretion.[8][2]

See also


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