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Fluoxymesterone

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Title: Fluoxymesterone  
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Subject: Anabolic steroid, Testosterone, Dihydrotestosterone, Anabolic steroids, Hydroxyflutamide
Collection: Alcohols, Anabolic Steroids, Androgens, Ketones, Organofluorides
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Fluoxymesterone

Fluoxymesterone
Systematic (IUPAC) name
9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Clinical data
AHFS/Drugs.com
MedlinePlus
Pregnancy
category
  • X
Legal status
  • Schedule III Controlled Substance
Pharmacokinetic data
Bioavailability 100% Oral
Metabolism Hepatic
Biological half-life 9.5 hours
Excretion urine
Identifiers
CAS Registry Number  Y
ATC code G03
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  Y
Chemical data
Formula C20H29FO3
Molecular mass 336.441 g/mol
 Y   

Fluoxymesterone (trade name Halotestin) is an anabolic steroid with strong androgenic properties that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. It is approximately 5 times as potent as testosterone.[1] The antitumor activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.

Like many C-17 alpha alkylated steroids, fluoxymesterone has poor binding to the androgen receptor. Even so, its actions are mediated by the androgen receptor, most-likely due to its prolonged plasma half-life.[2]

It is considered a very toxic oral drug.

Though the half-life of fluoxymesterone is about 9.2 hours.

References

  1. ^ Dr. K.V. Sastry (2008). Endocrinology and Reproductive Biology. Page 150. ISBN 81-7133-777-5.
  2. ^ Seth Roberts (2009). Anabolic Pharmacology.

Further reading

  • Daniels, R. C. (February 1, 2003). The Anabolic Steroid Handbook. Richard C Daniels. p. 80.  
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