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Flurbiprofen

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Title: Flurbiprofen  
Author: World Heritage Encyclopedia
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Subject: Felbinac, Ketoprofen, Aspirin, Propacetamol, Morazone
Collection: Non-Steroidal Anti-Inflammatory Drugs, Organofluorides, Phenyl Alkanoic Acids
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Flurbiprofen

Flurbiprofen
Systematic (IUPAC) name
(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
Clinical data
Trade names Ansaid, Ocufen, Strepfen
AHFS/Drugs.com
MedlinePlus
Pregnancy cat.
Legal status
  • POM
Routes Oral
Pharmacokinetic data
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Half-life 4.7-5.7 hours
Excretion Renal
Identifiers
CAS number  YesY
ATC code M01 , M02, R02, S01
PubChem
IUPHAR ligand
DrugBank
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
Synonyms (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid
PDB ligand ID FLP (, )
Chemical data
Formula C15H13FO2 
Mol. mass 244.261 g/mol
Physical data
Melt. point 117 °C (243 °F)
 YesY   

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis.[1] It is known as "Ansaid" marketed by Pfizer and "Froben" by Abbott.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges (Strepsils Intensive).

A single enantiomer of flurbiprofen, tarenflurbil [(R)-flurbiprofen)], is currently in clinical trials for the treatment of metastatic prostate cancer.

References

  1. ^ "Medical Dictionary, Houghton Mifflin Company". Retrieved July 21, 2010. 


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