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Title: Fluticasone  
Author: World Heritage Encyclopedia
Language: English
Subject: Mometasone furoate, Fluticasone/salmeterol, Budesonide, Prednisolone, Glucocorticoid
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
S-Fluoromethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
Clinical data
  • C for Intranasal and Inhaled
Legal status
Routes of
Intranasal, inhaled, topical cream or ointment
Pharmacokinetic data
Bioavailability 0.51% (Intranasal)
Protein binding 91%
Metabolism Intranasal
Hepatic (CYP3A4-mediated)
Biological half-life 10 hours
Excretion Renal
CAS Registry Number  N
80474-14-2 (propionate)
ATC code D07 R01 R03
PubChem CID:
DrugBank  N
ChemSpider  Y
Chemical data
Formula C22H27F3O4S
Molecular mass 444.508 g/mol

Fluticasone is a synthetic glucocorticoid.[1] Both the furoate and propionate ester prodrugs, fluticasone furoate and fluticasone propionate, are used as topical anti-inflammatories:[2]


  1. ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600,  
  2. ^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse's Drug Handbook 2012, Cengage Learning, p. 748,  
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