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Gp1bb

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Title: Gp1bb  
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Subject: Glycoprotein Ib, Platelet membrane glycoprotein, GP1BA, Glycoprotein IX, ITGA2B
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Gp1bb

Glycoprotein Ib (platelet), beta polypeptide
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; BDPLT1; BS; CD42C; GPIBB
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Glycoprotein Ib (platelet), beta polypeptide (GP1BB) also known as CD42c (Cluster of Differentiation 42c), is a human gene.[1] Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene.[1]

Interactions

GP1BB has been shown to interact with YWHAZ.[2][3][4]

See also

References

  1. ^ a b "Entrez Gene: GP1BB glycoprotein Ib (platelet), beta polypeptide". 
  2. ^ Calverley, D C; Kavanagh T J; Roth G J (February 1998). "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood (UNITED STATES) 91 (4): 1295–303.  
  3. ^ Du, X; Harris S J; Tetaz T J; Ginsberg M H; Berndt M C (July 1994). "Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex". J. Biol. Chem. (UNITED STATES) 269 (28): 18287–90.  
  4. ^ Feng, S; Christodoulides N; Reséndiz J C; Berndt M C; Kroll M H (January 2000). "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V". Blood (UNITED STATES) 95 (2): 551–7.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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