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GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the cannabinoid receptor subtype CB2, with an EC50 of 0.65nM and selectivity of around 1200x for CB2 over CB1 receptors.[1][2] Animal studies have shown it to possess antiinflammatory and anti-hyperalgesic effects at low doses, followed by ataxia and analgesic effects when the dose is increased.[3][4] Selective CB2 agonist drugs such as GW-405,833 are hoped to be particularly useful in the treatment of allodynia and neuropathic pain for which current treatment options are often inadequate.[5][6]
Tetrahydrocannabinol, 2-Arachidonyl glyceryl ether, Cannabidiol, Cannabinoid receptor type 1, 2-Arachidonoylglycerol
Ic50, Dose response curve, Ligand, Sigmoid function, Inflection point
Tetrahydrocannabinol, Gaba, Anandamide, Mammals, Rimonabant
Xenon, Methamphetamine, Caffeine, Acetylcholine, Amphetamine