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Title: Hoxc8  
Author: World Heritage Encyclopedia
Language: English
Subject: Homeobox, Transcription factors, NeuroD, EMX homeogene, Nur (biology)
Collection: Transcription Factors
Publisher: World Heritage Encyclopedia


Homeobox C8
Symbols  ; HOX3; HOX3A
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Homeobox protein Hox-C8 is a

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56.  
  • Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8.  
  • Simeone A, Mavilio F, Acampora D, et al. (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8.  
  • Cannizzaro LA, Croce CM, Griffin CA, et al. (1987). "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". Am. J. Hum. Genet. 41 (1): 1–15.  
  • Lawrence HJ, Stage KM, Mathews CH, et al. (1993). "Expression of HOX C homeobox genes in lymphoid cells". Cell Growth Differ. 4 (8): 665–9.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5.  
  • Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–7.  
  • Shi X, Yang X, Chen D, et al. (1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7.  
  • Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53.  
  • Bai S, Shi X, Yang X, Cao X (2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70.  
  • Wan M, Shi X, Feng X, Cao X (2001). "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25.  
  • Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82.  
  • Waltregny D, Alami Y, Clausse N, et al. (2002). "Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation". Prostate 50 (3): 162–9.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Bayarsaihan D, Enkhmandakh B, Makeyev A, et al. (2003). "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10358–63.  
  • Luo L, Yang X, Takihara Y, et al. (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature 427 (6976): 749–53.  

Further reading

  1. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460.  
  2. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3.  
  3. ^ a b "Entrez Gene: HOXC8 homeobox C8". 
  4. ^ Liu Y (Jan 2014). "Microarray-based identification of nerve growthpromoting genes in neurofibromatosis type I.". J Mol Med Rep 9 (1): 192–6.  
  5. ^ Bai, S; Shi X; Yang X; Cao X (March 2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. (UNITED STATES) 275 (12): 8267–70.  
  6. ^ Shi, X; Yang X; Chen D; Chang Z; Cao X (May 1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. (UNITED STATES) 274 (19): 13711–7.  


HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6[5] and Mothers against decapentaplegic homolog 1.[6]


See also


  • See also 1
  • Interactions 2
  • References 3
  • Further reading 4
  • External links 5

[4] type 1. neurofibromatosis HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients suffering from [3]

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