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Ici-190,622

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Title: Ici-190,622  
Author: World Heritage Encyclopedia
Language: English
Subject: Tracazolate, Cartazolate, Etazolate, Pyrazolopyridine, Anxiolytics
Collection: Alkenes, Alkynes, Amides, Anxiolytics, Gabaa Receptor Positive Allosteric Modulators, Pyrazolopyridines
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Ici-190,622

ICI-190,622
Systematic (IUPAC) name
4-amino-1-pent-3-ynyl-N-prop-2-enylpyrazolo[3,4-b]pyridine-5-carboxamide
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
Chemical data
Formula C15H17N5O 
Mol. mass 283.328 g/mol
 YesY   

ICI-190,622 is an anxiolytic drug used in scientific research. It is a pyrazolopyridine derivative, related to other anxiolytic compounds such as tracazolate, and more distantly to zaleplon. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1][2]

See also

References

  1. ^ Patel JB, Meiners BA, Salama AI, Malick JB, U'Prichard DC, Giles RE, Goldberg ME, Bare TM (April 1988). "Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622". Pharmacology, Biochemistry, and Behavior 29 (4): 775–9.  
  2. ^ Bare TM, McLaren CD, Campbell JB, Firor JW, Resch JF, Walters CP, Salama AI, Meiners BA, Patel JB (December 1989). "Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents". Journal of Medicinal Chemistry 32 (12): 2561–73.  



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