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Levoamphetamine

Levoamphetamine
Stereo, Kekulé, skeletal formula of levoamphetamine
Identifiers
CAS number  YesY
PubChem
ChemSpider  YesY
EC number
ChEBI  YesY
ChEMBL  YesY
Beilstein Reference 2432739
Gmelin Reference 1125855
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C9H13N
Molar mass 135.21 g mol−1
log P 1.789
Pharmacology
Routes of
administration
Oral
Legal status


-only(US)

Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Levoamphetamine (also levamfetamine (INN), (R)-amphetamine or (−)-amphetamine) is a psychostimulant known to increase wakefulness and concentration in association with decreased appetite and fatigue. Levoamphetamine is the levorotatory stereoisomer of the amphetamine molecule.

Contents

  • Chemistry 1
  • Formulations 2
    • Adderall 2.1
    • Benzedrine 2.2
  • See also 3
  • References 4

Chemistry

Levoamphetamine is the levorotary stereoisomer of the amphetamine molecule. Racemic amphetamine contains two optical isomers, dextroamphetamine and levoamphetamine.[2]

Formulations

Adderall

Adderall (nonproprietary name: dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine sulfate and amphetamine aspartate)[3] is an amphetamine pharmaceutical that contains 25% levoamphetamine salts and 75% dextroamphetamine salts.[2]

Benzedrine

Benzedrine was a racemic (equal parts) mixture of dextroamphetamine and levoamphetamine introduced in the United States as an inhaler in 1934 for nasal decongestion.[4] It was later discovered that amphetamine could treat narcolepsy and ADHD.[4]

See also

References

  1. ^ "Amphetamine - PubChem Public Chemical Project". The PubChem Project. USA: National Center for Biotechnology Information. 8 August 2005. Descriptors Computed from Structure. Retrieved 26 September 2011. 
  2. ^ a b "Adderall XR Prescribing Information". United States Food and Drug Administration. December 2013. Retrieved 30 December 2013. 
  3. ^ "National Drug Code Amphetamine Search Results". National Drug Code Directory. United States Food and Drug Administration. Archived from the original on 7 February 2014. Retrieved 16 December 2013. 
  4. ^ a b Heal DJ, Smith SL, Gosden J, Nutt DJ (June 2013). "Amphetamine, past and present – a pharmacological and clinical perspective". J. Psychopharmacol. 27 (6): 479–496.  
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