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Title: Loperamide/simethicone  
Author: World Heritage Encyclopedia
Language: English
Subject: WikiProject Pharmacology/Cleanup listing, Antidiarrhoeals, Synthetic opioids, Mu-opioid agonists, List of opioids
Publisher: World Heritage Encyclopedia


Combination of
Loperamide Antidiarrheal
Simethicone Gas reducer
Clinical data
Trade names Imodium Multi-Symptom Relief
  • US: C (Risk not ruled out)
Legal status
Routes of

Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc.

Loperamide is a μ-opioid receptor agonist that works in the intestines.[1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen.

Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles in the intestinal tract, making them easier to pass. Simethicone is not absorbed from the gastrointestinal tract so there are no systemic side effects.[2]


Anti-diarrheal medications should be avoided if diarrhea is secondary to an infection. Avoid using such products in the presence of fever, black stools, bloody stools, or stools containing mucus.[3]


  1. ^ Imodium,
  2. ^ Simethicone,
  3. ^ "Imodium Product Page". Retrieved 2012-06-19. 

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