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Title: Megakaryoblast  
Author: World Heritage Encyclopedia
Language: English
Subject: Promegakaryocyte, Megakaryocyte–erythroid progenitor cell, Megakaryocyte, CFU-E, CFU-Meg
Collection: Leukocytes
Publisher: World Heritage Encyclopedia


Code TH H2.
Anatomical terminology

A megakaryoblast is a precursor cell to a promegakaryocyte, which in turn becomes a megakaryocyte during haematopoiesis. It is the beginning of the thrombocytic series.


  • Origin 1
  • Structure 2
  • References 3
  • External links 4


The megakaryoblast derives from a CFU-Me colony unit of pluripotential hemopoietic stem cells. (Some sources use the term "CFU-Meg" to identify the CFU.[1])


These cells tend to range from 8μm to 30μm, owing to the variation in size between different megakaryoblasts.[2] The nucleus is three to five times the size of the cytoplasm, and is generally round or oval in shape. Several nucleoli are visible, while the chromatin varies from cell to cell, ranging from fine to heavy and dense. The cytoplasm is generally basophilic and stains blue. In smaller cells, it contains no granules, but larger megakaryoblasts may contain fine granules.[3]


  1. ^ Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107.  
  2. ^ McClatchey, Kenneth, ed. (2002). Clinical Laboratory Medicine. Lippincott Williams & Wilkins. p. 802.  
  3. ^ Anderson, Shauna (2013). Anderson's Atlas of Hematology. Lippincott Williams & Wilkins. p. 129.  

External links

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  • Life cycle

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