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Mesocortical pathway

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Title: Mesocortical pathway  
Author: World Heritage Encyclopedia
Language: English
Subject: Ventral tegmental area, Nigrostriatal pathway, Dopaminergic pathways, Mesolimbic pathway, Dopamine
Collection: Central Nervous System Pathways
Publisher: World Heritage Encyclopedia

Mesocortical pathway

The mesocortical pathway is shown here in blue, projecting to the prefrontal cortex from the VTA.

The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the cerebral cortex, in particular the frontal lobes. It is one of the four major dopamine pathways in the brain. It is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe), and is thought to be involved in cognitive control, motivation, and emotional response.[1][2]

This pathway may be the brain system that is abnormal or functioning abnormally in psychoses, such as schizophrenia.[3] It is thought to be associated with the negative symptoms of schizophrenia, which include avolition, alogia and flat affect. This pathway is closely associated with the mesolimbic pathway, which is also known as the mesolimbic reward pathway.


  • Other dopamine pathways 1
  • See also 2
  • References 3
  • External links 4

Other dopamine pathways

Other major dopamine pathways include:

See also


  1. ^ Malenka EJ, Nestler SE, Hyman RC (2009). "Chapter 13: Higher Cognitive Function and Behavioral Control". Molecular neuropharmacology: a foundation for clinical neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 318.  
  2. ^ Bidwell LC, McClernon FJ, Kollins SH (August 2011). "Cognitive enhancers for the treatment of ADHD". Pharmacol. Biochem. Behav. 99 (2): 262–274.  
  3. ^ Diaz, Jaime. How Drugs Influence Behavior. Englewood Cliffs: Prentice Hall, 1996.

External links

  • Diagram
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