World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0004872079
Reproduction Date:

Title: Mesoridazine  
Author: World Heritage Encyclopedia
Language: English
Subject: Thioridazine, Butaclamol, Acetophenazine, Gevotroline, Promazine
Collection: Phenothiazines, Piperidines, Sulfoxides
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}- 2-methylsulfinyl- 10H-phenothiazine
Clinical data
Trade names Serentil
  • US: C (Risk not ruled out)
Legal status
  • (Prescription only)
Routes of
oral, intravenous
Pharmacokinetic data
Protein binding 4%
Metabolism Hepatic/Renal
Biological half-life 24 to 48 hours
Excretion Biliary and renal
CAS Registry Number  Y
ATC code N05
PubChem CID:
DrugBank  Y
ChemSpider  Y
Chemical data
Formula C21H26N2OS2
Molecular mass 386.576 g/mol
Physical data
Melting point 130 °C (266 °F)
Solubility in water insoluble mg/mL (20 °C)

Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drug's name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure.

It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects.

Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome.

Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram.[1]

It currently appears to be unavailable worldwide.


  1. ^ [2]

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.