World Library  
Flag as Inappropriate
Email this Article

Muscarinic acetylcholine receptor M5

Article Id: WHEBN0013982324
Reproduction Date:

Title: Muscarinic acetylcholine receptor M5  
Author: World Heritage Encyclopedia
Language: English
Subject: Clozapine, Acetylcholine receptor, Parasympathetic nervous system, Thioridazine, Amitriptyline, Muscarinic acetylcholine receptor, Nortriptyline, Doxepin, Zotepine, Muscarinic agonist
Publisher: World Heritage Encyclopedia

Muscarinic acetylcholine receptor M5

Cholinergic receptor, muscarinic 5
CHRM5 Gene
RNA expression pattern

The human muscarinic acetylcholine receptor M5, encoded by the cyclic AMP levels and downregulate the activity of protein kinase A (PKA).


No highly selective agonists or antagonists for the M5 receptor have been discovered as of 2009, but several non-selective muscarinic agonists and antagonists have significant affinity for M5.


  • Milameline ((E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde-O-methyloxime, CAS# 139886-32-1)
  • Sabcomeline

Positive allosteric modulators

  • VU-0238429: EC50 = 1.16 μM; >30-fold selectivity versus M1 and M3, inactive at M2 and M4.[1]


See also


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.