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Niclosamide

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Niclosamide

Niclosamide
Systematic (IUPAC) name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Clinical data
Trade names Niclocide, Fenasal, Phenasal etc.[1]
AHFS/Drugs.com
Identifiers
CAS Registry Number  N
ATC code P02 QP52
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEMBL  Y
Chemical data
Formula C13H8Cl2N2O4
Molecular mass 327.119 g/mol
 N   

Niclosamide (trade name Niclocide[1]) is a teniacide in the anthelmintic family especially effective against cestodes that infect humans and many other animals. It is a salicylanilide compound (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydrobenzamide) also used as a piscicide. While antihelmintics are a drug family used to treat worm infections, niclosamide is used specifically to treat tapeworms and is not effective against other worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight. It is not usually considered the drug of choice for treating cestode infection in humans or animals because of its side effects, though it remains highly effective and is generally inexpensive.[2]

Along with health system.[4]

Contents

  • Side effects 1
  • Mechanism of action 2
  • References 3
  • More reading 4
  • External links 5

Side effects

The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis. Rarely, dizziness, skin rash, drowsiness, perianal itching, or an unpleasant taste occur. For some of these reasons, praziquantel is a preferable and equally effective treatment for tapeworm infestation.

Mechanism of action

Niclosamide inhibits glucose uptake, oxidative phosphorylation, and anaerobic metabolism in the tapeworm.[5]

References

  1. ^ a b PubChem 4477
  2. ^ Jim E. Riviere; Mark G. Papich (13 May 2013). Veterinary Pharmacology and Therapeutics. John Wiley & Sons. p. 1096.  
  3. ^ Staphylococcus aureusRepurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant at PLOS
  4. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 
  5. ^ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature 221 (5185): 1016–8.  

More reading

  • Taber, Clarence Wilbur; Venes, Donald; Thomas, Clayton L. (2001). Taber's cyclopedic medical dictionary. Philadelphia: F.A.Davis Co. 

External links

  • Niclosamide in the Pesticide Properties DataBase (PPDB)
  • "MedlinePlus Drug Information: Niclosamide (Oral)". MedlinePlus. U.S. National Library of Medicine. 1995-06-23. Archived from the original on 2006-12-16. 
  • "Helminths: Cestode (tapeworm) infection: Niclosamide". WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition.  
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