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Title: Nizofenone  
Author: World Heritage Encyclopedia
Language: English
Subject: Nootropics, SIB-1553A, TC-1827, Adafenoxate, Linopirdine
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number
ATC code N06
ChemSpider  YesY
Chemical data
Formula C21H21ClN4O3 
Mol. mass 412.869 g/mol

Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.[1][2][3][4]


  1. ^ Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. Journal of Neurosurgery. 1986 Mar;64(3):420-6. PMID 3512795
  2. ^ Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Advances in Experimental Medicine and Biology. 1988;222:403-10. PMID 3364265
  3. ^ Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovascular and Brain Metabolism Reviews. 1993 Winter;5(4):264-76. PMID 8110594
  4. ^ Matsumoto Y, Aihara K, Kamata T, Goto N. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. European Journal of Pharmacology. 1994 Sep 1;262(1-2):157-61. PMID 7813567

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