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Picolinic acid

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Title: Picolinic acid  
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Subject: Matrix-assisted laser desorption/ionization, 3-Hydroxypicolinic acid
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Picolinic acid

Template:Chembox ChEMBL
Picolinic acid

CAS number 98-98-6 YesY
PubChem 1018
ChemSpider 993 YesY
ChEBI CHEBI:28747 YesY
Jmol-3D images Image 1
Molecular formula C6H5NO2
Molar mass 123.11 g mol−1
Appearance White to tan crystalline solid
Melting point

136-138 °C

Solubility in water 887 g/L[1]
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Picolinic acid is a pyridine compound with a carboxyl side chain at the 2-position. It is an isomer of nicotinic acid, which has the carboxyl side chain at the 3-position. It is a catabolite of the amino acid tryptophan.

Chelating properties

Picolinic acid acts as a chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body. Template:Cn-span and for the quantitative detection of calcium.

The acid is believed to form a complex with zinc that may facilitate the passage of zinc through the gastrointestinal wall and into the circulatory system. A study of rats found that dietary picolinic acid increases the turnover and excretion of zinc.[2] Other results suggest that picolinic acid is a chelator which interacts with metals aside from zinc.[3] Commercially available picolinic acid is used as an intermediate to produce pharmaceuticals (especially local anesthetics) and metal salts for the application of nutritional supplements.

See also


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