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Prosultiamine

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Title: Prosultiamine  
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Subject: Thiamine, Human T-lymphotropic virus, Beta-Tocopherol, Beta-Tocotrienol, Menadiol
Collection: Amides, Amines, Organic Disulfides, Pyrimidines, Vitamin B1
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Prosultiamine

Prosultiamine
Systematic (IUPAC) name
N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
Clinical data
AHFS/Drugs.com
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
Chemical data
Formula C15H24N4O2S2 
Mol. mass 356.51 g/mol

Prosultiamine (Alinamin, Binova, Jubedel, Taketron, Thiobeta, Thiotiamina), also known as thiamine propyl disulfide (TPD), is a disulfide thiamine derivative developed in Japan in the 1950s as a treatment for vitamin B1 deficiency.[1][2] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[3][4] It is also a potential treatment for HTLV, since it has been shown to reduce viral load and symptoms.[5]

See also

References

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers.  
  2. ^ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall.  
  3. ^ Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine 74 (4): 529–34.  
  4. ^ Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–8.  
  5. ^ Nervous System Disease: A New Outlet for an Old Drug?



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