World Library  
Flag as Inappropriate
Email this Article

Q fever

Article Id: WHEBN0000056480
Reproduction Date:

Title: Q fever  
Author: World Heritage Encyclopedia
Language: English
Subject: List of notifiable diseases, One-Million-Liter Test Sphere, United States biological defense program, List of cutaneous conditions, War Research Service
Publisher: World Heritage Encyclopedia

Q fever

Q fever
Classification and external resources
ICD-10 A78
ICD-9 083.0
DiseasesDB 11093
MedlinePlus 001337
eMedicine med/1982 ped/1973
MeSH D011778

Q fever is a disease caused by infection with [3] The bacterium is an obligate intracellular pathogen.


Image A: A normal chest X-ray Image B: Q fever pneumonia

Q-fever was first described in 1935 by Edward Holbrook Derrick[4] in abattoir workers in Brisbane, Queensland, Australia. The "Q" stands for "query" and was applied at a time when the causative agent was unknown; it was chosen over suggestions of "abattoir fever" and "Queensland rickettsial fever", to avoid directing negative connotations at either the cattle industry or the state of Queensland.[5]

The pathogen of Q fever was discovered in 1937, when Frank Macfarlane Burnet and Mavis Freeman isolated the bacterium from one of Derrick’s patients.[6] It was originally identified as a species of Rickettsia. H.R. Cox and Gordon Davis elucidated the transmission when they isolated it from ticks in Montana, USA in 1938.[7] It is a zoonotic disease whose most common animal reservoirs are cattle, sheep and goats. Coxiella burnetii — named for Cox and Burnet — is no longer regarded as closely related to Rickettsiae, but as similar to Legionella and Francisella, and is a proteobacterium.

Signs and symptoms

Incubation period is usually two to three weeks.[8] The most common manifestation is mild flu-like symptoms with abrupt onset of fever, malaise, profuse perspiration, severe headache, myalgia (muscle pain), joint pain, loss of appetite, upper respiratory problems, dry cough, pleuritic pain, chills, confusion and gastrointestinal symptoms, such as nausea, vomiting and diarrhea. The fever lasts approximately seven to 14 days.

Approximately half of infected individuals exhibit no symptoms.[8]

During its course, the disease can progress to an atypical pneumonia, which can result in a life-threatening acute respiratory distress syndrome (ARDS), whereby such symptoms usually occur during the first four to five days of infection.

Less often, Q fever causes (granulomatous) hepatitis, which may be asymptomatic or becomes symptomatic with malaise, fever, liver enlargement (hepatomegaly) and pain in the right upper quadrant of the abdomen. Whereas transaminase values are often elevated, jaundice is uncommon. Retinal vasculitis is a rare manifestation of Q fever.[9]

The chronic form of Q fever is virtually identical to inflammation of the inner lining of the heart (endocarditis),[10] which can occur months or decades following the infection. It is usually fatal if untreated. However, with appropriate treatment, the mortality falls to around 10%.

Clinical signs in animals

Cattle, goats and sheep are most commonly infected, and can serve as a reservoir for the bacteria. Q fever is a well recognized cause of abortions in ruminants and in pets. C. burnetii infection in dairy cattle has been well documented and its association with reproductive problems in these animals has been reported in Canada, USA, Cyprus, France, Hungary, Japan, Switzerland and West Germany.[11] For instance, in a study published in 2008,[12] a significant association has been shown between the herds’ seropositivity and typical clinical signs of Q Fever observed such as abortion, stillbirth, weak calves and repeat breeding. Moreover, experimental inoculation of C. burnetii in cattle induced not only respiratory disorders and cardiac failures (myocarditis) but also frequent abortions and irregular repeat breedings.[13]

Appearance and incidence

C. burnetii, the Q fever-causing agent

The pathogenic agent is found everywhere except milk, meat, wool and particularly birthing products. Ticks can transfer the pathogenic agent to other animals. Transfer between humans seems extremely rare and has so far been described in very few cases.

Some studies have shown more men to be affected than women,[15][16] which may be attributed to different employment rates in typical professions.

"At risk" occupations include, but are not limited to:


Q fever management algorithm from the CDC

Diagnosis is usually based on serology[17][18] (looking for an antibody response) rather than looking for the organism itself. Serology allows to detect chronic infection as high antibody levels are found against the virulent form of the bacterium. Molecular detection of bacterial DNA is increasingly used. Culture is technically difficult and not routinely available in most microbiology laboratories.

Q fever can cause endocarditis (infection of the heart valves) which may require transoesophageal echocardiography to diagnose. Q fever hepatitis manifests as an elevation of ALT and AST, but a definitive diagnosis is only possible on liver biopsy, which shows the characteristic fibrin ring granulomas.[19]


Treatment of the acute Q fever with antibiotics is very effective and should take place in consultation with an infectious diseases specialist. Commonly used are doxycycline, tetracycline, chloramphenicol, ciprofloxacin, ofloxacin, and hydroxychloroquine. The chronic form is more difficult to treat and can require up to four years of treatment with doxycycline and quinolones or doxycycline with hydroxychloroquine.

Q fever in pregnancy is especially difficult to treat because doxycycline and ciprofloxacin are contraindicated in pregnancy. The preferred treatment is five weeks of co-trimoxazole.[20]


Protection is offered by Q-Vax, a whole-cell, inactivated vaccine developed by an Australian vaccine manufacturing company, CSL.[21] The intradermal vaccination is composed of killed Coxiella burnetii organisms. Skin and blood tests should be done before vaccination to identify pre-existing immunity, because vaccinating subjects who already have an immunity can result in a severe local reaction. After a single dose of vaccine, protective immunity lasts for many years. Revaccination is not generally required. Annual screening is typically recommended.[22]

In 2001, Australia introduced a national Q fever vaccination program for people working in "at risk" occupations.

The Soviet Union had earlier developed a killed vaccine, but its side effects prevented its licensing abroad.

Preliminary results suggest vaccination of animals may be a method of control. Published trials proved that use of a registered Phase I vaccine (Coxevac) in infected farms is a tool of major interest to manage or prevent early or late abortion, repeat breeding, anoestrus, silent oestrus, metritis and decreases in milk yield when C. burnetii is the major cause of these problems.[23][24]

Biological warfare

Q fever has been developed as a biological weapon.[25] The United States investigated Q fever as a potential biological warfare agent in the 1950s, with eventual standardization as agent OU. At Fort Detrick and Dugway Proving Ground, human trials were conducted on Whitecoat volunteers to determine the median infective dose (18 MICLD50/person i.h.) and course of infection. The Deseret Test Center dispensed biological Agent OU with ships and aircraft, during Project 112 and Project SHAD.[26] As a standardized biological, it was manufactured in large quantities at Pine Bluff Arsenal, with 5,098 gallons in the arsenal in bulk at the time of demilitarization in 1970. Q fever is currently ranked as a "Category B" bioterrorism agent by the CDC.[27] It can be contagious, and is very stable in aerosols in a wide range of temperatures. Q fever microorganisms may survive on surfaces up to 60 days. It is considered a good agent in part because its ID50 (number of bacilli needed to infect 50% of individuals) is considered to be 1, making it the lowest known to man.

In popular culture

An early mention of Q fever was important in one of the early Dr. Kildare films (1939, Calling Dr. Kildare). Kildare's mentor Dr. Gillespie (Lionel Barrymore) tires of his protege working fruitlessly on "exotic diagnoses" ("I think it's Q fever!") and sends him to work in a neighborhood clinic instead.[28][29]

Q fever was also highlighted in an episode of the U.S. television medical drama House ("The Dig", Season 7, Episode 18).


  1. ^ Beare PA, Samuel JE, Howe D, Virtaneva K, Porcella SF, Heinzen RA (April 2006). "Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons". J. Bacteriol. 188 (7): 2309–24.  
  2. ^ "Q fever". 
  3. ^ Q fever caused by Coxiella burnetii
  4. ^ Derrick EH. Q" fever a new fever entity: clinical features. diagnosis, and laboratory investigation. Med J Aust. 1937;11:281-299.
  5. ^ Joseph E. McDade (1990). "Historical Aspects of Q Fever". In Thomas J. Marrie. Q Fever, Volume I: The Disease. CRC Press. p. 8.  
  6. ^ Burnet FM, Freeman M. Experimental studies on the virus of “Q” fever. Med J Aust 1937; 2: 299-305.
  7. ^ Davis, G. E., and H. R. Cox. 1938. A filter-passing infectious agent isolated from ticks. I. Isolation from Dermacentor andersonii, reactions in animals, and filtration. Public Health Rep. 53:2259-2282.
  8. ^ a b Anderson, Alicia & McQuiston, Jennifer (2011). "Q Fever". In Brunette, Gary W. et al. CDC Health Information for International Travel: The Yellow Book. Oxford University Press. p. 270.  
  9. ^ Kuhne F, Morlat P, Riss I, et al. (1992). "Is A29, B12 vasculitis caused by the Q fever agent? (Coxiella burnetii)". J Fr Ophtalmol (in French) 15 (5): 315–21.  
  10. ^ Karakousis PC, Trucksis M, Dumler JS (June 2006). "Chronic Q fever in the United States". J. Clin. Microbiol. 44 (6): 2283–7.  
  11. ^ To, H; Sakai, R; Shirota, K; Kano, C; Abe, S; Sugimoto, T; Takehara, K; Morita, C; Takashima, I; Maruyama, T; Yamaguchi, T; Fukushi, H; Hirai, K (1998). "Coxiellosis in domestic and wild birds from Japan". Journal of wildlife diseases 34 (2): 310–6.  
  12. ^ Czaplicki, G; Houtain, JY; Mullender, C; Porter, SR; Humblet, MF; Manteca, C; Saegerman, C (2012). "Apparent prevalence of antibodies to Coxiella burnetii (Q fever) in bulk tank milk from dairy herds in southern Belgium". Veterinary journal (London, England : 1997) 192 (3): 529–31.  
  13. ^ Plommet, M; Capponi, M; Gestin, J; Renoux, G (1973). "Fièvre Q expérimentale des bovins". Annales de recherches vétérinaires (in French) 4 (2): 325–346. 
  14. ^ Cutler SJ, Bouzid M, Cutler RR (April 2007). "Q fever". J. Infect. 54 (4): 313–8.  
  15. ^ Domingo P, Muñoz C, Franquet T, Gurguí M, Sancho F, Vazquez G (October 1999). "Acute Q fever in adult patients: report on 63 sporadic cases in an urban area". Clin. Infect. Dis. 29 (4): 874–9.  
  16. ^ Dupuis G, Petite J, Péter O, Vouilloz M (June 1987). "An important outbreak of human Q fever in a Swiss Alpine valley". Int J Epidemiol 16 (2): 282–7.  
  17. ^ Maurin M, Raoult D (October 1999). "Q fever". Clin. Microbiol. Rev. 12 (4): 518–53.  
  18. ^ Scola BL (October 2002). "Current laboratory diagnosis of Q fever". Semin Pediatr Infect Dis 13 (4): 257–62.  
  19. ^ van de Veerdonk FL, Schneeberger PM. (2006). "Patient with fever and diarrea". Clin Infect Dis 42 (7): 1051–2.  
  20. ^ Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A (2007). "Managing Q fever during pregnancy: The benefits of long-term Cotrimoxazole therapy". Clin Infect Dis 45 (5): 548–555.  
  21. ^
  22. ^
  23. ^ Camuset, P; Remmy, D (2008). "Q Fever (Coxiella burnetii) Eradication in a Dairy Herd by Using Vaccination with a Phase 1 Vaccine". Budapest: XXV World Buiatrics Congress. 
  24. ^ Hogerwerf, L; Van Den Brom, R; Roest, HI; Bouma, A; Vellema, P; Pieterse, M; Dercksen, D; Nielen, M (2011). "Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, the Netherlands". Emerging infectious diseases 17 (3): 379–86.  
  25. ^ Madariaga MG, Rezai K, Trenholme GM, Weinstein RA (November 2003). "Q fever: a biological weapon in your backyard". Lancet Infect Dis 3 (11): 709–21.  
  26. ^ Deseret Test Center, Project SHAD, Shady Grove revised fact sheet
  27. ^ Seshadri R, Paulsen IT, Eisen JA, et al. (April 2003). "Complete genome sequence of the Q-fever pathogen Coxiella burnetii". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5455–60.  
  28. ^ "Calling Dr. Kildare". Movie Mirrors Index. Retrieved 30 April 2013. 
  29. ^ Kalisch, PA; Kalisch, BJ (1985). "When Americans called for Dr. Kildare: images of physicians and nurses in the Dr. Kildare and Dr. Gillespie movies, 1937–1947" (PDF). Medical Heritage 1 (1): 348–363.  

External links

  • Q fever at the CDC
  • Coxiella burnetii genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.