Reticular pigmented anomaly of the flexures

Reticular pigmented anomaly of the flexures
Classification and external resources
OMIM 179850

Reticular pigmented anomaly of the flexures (also known as "Dark dot disease," and "Dowling–Degos' disease") is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.[1]:856 It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.[2]

Dark dot disease is associated with KRT5.[3]

See also

References


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