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A rash due to rubella on a child's back. The area affected is similar to that of measles but the rash is less intensely red.
Classification and external resources
Specialty Infectious disease
ICD-10 B06
ICD-9-CM 056
DiseasesDB 11719
MedlinePlus 001574
eMedicine emerg/388 peds/2025 derm/259
MeSH D012409

Rubella, also known as German measles or three-day measles,[1] is an Americas officially free of rubella transmission.[7][8]


  • Signs and symptoms 1
    • Congenital rubella syndrome 1.1
  • Cause 2
  • Diagnosis 3
  • Prevention 4
  • Treatment 5
  • Prognosis 6
  • Epidemiology 7
  • History 8
  • Etymology 9
  • See also 10
  • References 11
  • External links 12

Signs and symptoms

Young boy displaying the characteristic maculopapular rash of rubella.[9]
Generalized rash on the abdomen due to rubella

Rubella has symptoms that are similar to those of flu. However, the primary symptom of rubella virus infection is the appearance of a rash (exanthem) on the face which spreads to the trunk and limbs and usually fades after three days (that is why it is often referred to as three-day measles). The facial rash usually clears as it spreads to other parts of the body. Other symptoms include low grade fever, swollen glands (sub occipital & posterior cervical lymphadenopathy), joint pains, headache, and conjunctivitis.[10]

The swollen glands or lymph nodes can persist for up to a week and the fever rarely rises above 38 oC (100.4 oF). The rash of German measles is typically pink or light red. The rash causes itching and often lasts for about three days. The rash disappears after a few days with no staining or peeling of the skin. When the rash clears up, the skin might shed in very small flakes where the rash covered it. Forchheimer's sign occurs in 20% of cases, and is characterized by small, red papules on the area of the soft palate.[11]

Rubella can affect anyone of any age and is generally a mild disease, rare in infants or those over the age of 40. The older the person is the more severe the symptoms are likely to be. Up to 60% of older girls or women experience joint pain or arthritic type symptoms with rubella.[12]

In children rubella normally causes symptoms which last two days and include:[13]

  • Rash beginning on the face which spreads to the rest of the body.
  • Low fever of less than 38.3 °C (101 °F).
  • Posterior cervical lymphadenopathy.[14]

In older children and adults additional symptoms may be present including:[13]

  • Swollen glands
  • Coryza (cold like symptoms)
  • Aching joints (especially in young women)

Serious problems can occur including the following:

  • Brain infections
  • Bleeding problems.
  • Birth Defects (Congenital)
  • Cataracts
  • Glaucoma
  • Heart Defects
  • Hearing Loss [15]

Coryza in rubella may convert to pneumonia, either direct viral pneumonia or secondary bacterial pneumonia, and bronchitis (either viral bronchitis or secondary bacterial bronchitis).[16]

Congenital rubella syndrome

Cataracts due to congenital rubella syndrome

Rubella can cause first trimester. CRS is the main reason a vaccine for rubella was developed.[18]

Many mothers who contract rubella within the first critical trimester either have a miscarriage or a still born baby. If the baby survives the infection, it can be born with severe heart disorders ([18] For these reasons, rubella is included on the TORCH complex of perinatal infections.

About 10,000 cases of this condition occur each year.[19]


Transmission electron micrograph of rubella virus

The disease is caused by Rubella virus, a togavirus that is enveloped and has a single-stranded RNA genome.[20] The virus is transmitted by the respiratory route and replicates in the nasopharynx and lymph nodes. The virus is found in the blood 5 to 7 days after infection and spreads throughout the body. The virus has teratogenic properties and is capable of crossing the placenta and infecting the fetus where it stops cells from developing or destroys them.[10] During this incubation period, the patient is contagious typically for about one week before he/she develops a rash and for about one week thereafter.

Increased susceptibility to infection might be inherited as there is some indication that HLA-A1 or factors surrounding A1 on extended haplotypes are involved in virus infection or non-resolution of the disease.[21] [22]


Rubella virus specific IgM antibodies are present in people recently infected by Rubella virus but these antibodies can persist for over a year and a positive test result needs to be interpreted with caution.[23] The presence of these antibodies along with, or a short time after, the characteristic rash confirms the diagnosis.[24]


Rubella infections are prevented by active immunisation programs using live, disabled virus vaccines. Two live attenuated virus vaccines, RA 27/3 and Cendehill strains, were effective in the prevention of adult disease. However their use in prepubertile females did not produce a significant fall in the overall incidence rate of CRS in the UK. Reductions were only achieved by immunisation of all children.

The vaccine is now usually given as part of the MMR vaccine. The WHO recommends the first dose be given at 12 to 18 months of age with a second dose at 36 months. Pregnant women are usually tested for immunity to rubella early on. Women found to be susceptible are not vaccinated until after the baby is born because the vaccine contains live virus.[25]

The immunisation program has been quite successful. Cuba declared the disease eliminated in the 1990s, and in 2004 the Centers for Disease Control and Prevention announced that both the congenital and acquired forms of rubella had been eliminated from the United States.[26][27]

Screening for rubella susceptibility by history of vaccination or by serology is recommended in the United States for all women of childbearing age at their first preconception counseling visit to reduce incidence of congenital rubella syndrome (CRS).[28] It is recommended that all susceptible non-pregnant women of childbearing age should be offered rubella vaccination.[28] Due to concerns about possible teratogenicity, use of MMR vaccine is not recommended during pregnancy.[28] Instead, susceptible pregnant women should be vaccinated as soon as possible in the postpartum period.[28]


There is no specific treatment for Rubella; however, management is a matter of responding to symptoms to diminish discomfort. Treatment of newborn babies is focused on management of the complications. Congenital heart defects and cataracts can be corrected by direct surgery.[29]

Management for ocular congenital rubella syndrome (CRS) is similar to that for age-related macular degeneration, including counseling, regular monitoring, and the provision of low vision devices, if required.[30]


Rubella infection of children and adults is usually mild, self-limiting and often asymptomatic. The prognosis in children born with CRS is poor.[31]


Rubella is a disease that occurs worldwide. The virus tends to peak during the spring in countries with temperate climates. Before the vaccine to rubella was introduced in 1969, widespread outbreaks usually occurred every 6–9 years in the United States and 3–5 years in Europe, mostly affecting children in the 5-9 year old age group.[32] Since the introduction of vaccine, occurrences have become rare in those countries with high uptake rates.

Vaccination has interrupted the transmission of rubella in the Americas: no endemic case has been observed since February 2009.[33] Since the virus can always be reintroduced from other continents, the population still need to remain vaccinated to keep the western hemisphere free of rubella. During the epidemic in the U.S. between 1962–1965, rubella virus infections during pregnancy were estimated to have caused 30,000 still births and 20,000 children to be born impaired or disabled as a result of CRS.[34][35] Universal immunisation producing a high level of herd immunity is important in the control of epidemics of rubella.[36]

In the UK, there remains a large population of men susceptible to rubella who have not been vaccinated. Outbreaks of rubella occurred amongst many young men in the UK in 1993 and in 1996 the infection was transmitted to pregnant women, many of whom were immigrants and were susceptible. Outbreaks still arise, usually in developing countries where the vaccine is not as accessible.[37]

In Japan, 15,000 cases of rubella and 43 cases of congenital rubella syndrome were reported to the National Epidemiological Surveillance of Infectious Diseases between October 15, 2012, and March 2, 2014 during the 2012–13 rubella outbreak in Japan. They mainly occurred in men of ages 31 to 51 and young adults aged 24-34. [38]


Rubella was first described in the mid-eighteenth century. Friedrich Hoffmann made the first clinical description of rubella in 1740,[39] which was confirmed by de Bergen in 1752 and Orlow in 1758.[40]

In 1814, George de Maton first suggested that it be considered a disease distinct from both measles and scarlet fever. All these physicians were German, and the disease was known as Rötheln (contemporary German Röteln), hence the common name of "German measles".[41] Henry Veale, an English Royal Artillery surgeon, described an outbreak in India. He coined the name "rubella" (from the Latin word, meaning "little red") in 1866.[39][42][43][44]

It was formally recognised as an individual entity in 1881, at the International Congress of Medicine in London.[45] In 1914, Alfred Fabian Hess theorised that rubella was caused by a virus, based on work with monkeys.[46] In 1938, Hiro and Tosaka confirmed this by passing the disease to children using filtered nasal washings from acute cases.[43]

In 1940, there was a widespread epidemic of rubella in Australia. Subsequently, ophthalmologist Norman McAllister Gregg found 78 cases of congenital cataracts in infants and 68 of them were born to mothers who had caught rubella in early pregnancy.[42][43] Gregg published an account, Congenital Cataract Following German Measles in the Mother, in 1941. He described a variety of problems now known as congenital rubella syndrome (CRS) and noticed that the earlier the mother was infected, the worse the damage was. Since no vaccine was yet available, some popular magazines promoted the idea of "German measles parties" for infected children to spread the disease to other children (especially girls) to immunize them for life and protect them from later catching the disease when pregnant.[47] The virus was isolated in tissue culture in 1962 by two separate groups led by physicians Parkman and Weller.[42][44]

There was a pandemic of rubella between 1962 and 1965, starting in Europe and spreading to the United States.[44] In the years 1964–65, the United States had an estimated 12.5 million rubella cases. This led to 11,000 miscarriages or therapeutic abortions and 20,000 cases of congenital rubella syndrome. Of these, 2,100 died as neonates, 12,000 were deaf, 3,580 were blind, and 1,800 were mentally retarded. In New York alone, CRS affected 1% of all births [48][49]

In 1969 a live attenuated virus vaccine was licensed.[43] In the early 1970s, a triple vaccine containing attenuated measles, mumps and rubella (MMR) viruses was introduced.[44] By 2006, confirmed cases in the Americas had dropped below 3000 a year. However, a 2007 outbreak in Argentina, Brazil, and Chile pushed the cases to 13,000 that year.[7]

On January 22, 2014, the [52] The declaration was made after 165 million health records and genetically confirming that all recent cases were causing by known imported strains of the virus. Rubella is still common in some regions of the world and Susan E. Reef, head of a global immunization effort, said there was no chance it would be eradicated worldwide before 2020.[7]


The name rubella is sometimes confused with rubeola, an alternative name for measles in English-speaking countries; the diseases are unrelated.[53][54] In some other European languages, like Spanish, rubella and rubeola are synonyms, and rubeola is not an alternative name for measles.[55] Thus, in Spanish, "rubeola" refers to rubella and "sarampión" refers to measles.

See also


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External links

  • Rubella at Wong's Virology.
  • Immunization Action Coalition: Rubella
  • Rubella risks during different periods of pregnancy
  • DermNet viral/rubella
  • Centers for Disease Control and Prevention (2012). "Ch. 19: Rubella". In Atkinson W, Wolfe S, Hamborsky J. Epidemiology and Prevention of Vaccine-Preventable Diseases (12th ed.). Washington DC: Public Health Foundation. pp. 275–290. 
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