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Title: Slc11a1  
Author: World Heritage Encyclopedia
Language: English
Subject: Solute carrier family, Arterial tortuosity syndrome, Achondrogenesis type 1B, SLC2A13, SLC2A14
Publisher: World Heritage Encyclopedia


Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Symbols  ; LSH; NRAMP; NRAMP1
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.[1][2][3] This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.[4] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[3]

See also


  1. ^ Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P (Dec 1994). "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". J Exp Med 180 (5): 1741–52.  
  2. ^ Kishi F (Dec 1994). "Isolation and characterization of human Nramp cDNA". Biochem. Biophys. Res. Commun. 204 (3): 1074–80.  
  3. ^ a b "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1". 
  4. ^ Teras, IuKh.; Ryĭgas, EM.; Kazakova, II.; Ranne, KhP.; Trapido, LE. (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases].". Ter Arkh 52 (3): 123–5.  

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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