| Solute carrier organic anion transporter family, member 1B3 |
|---|
| Identifiers |
|---|
| SLCO1B3 Gene |
|---|
| Gene Ontology |
| Molecular function |
• organic anion transmembrane transporter activity
|
| Cellular component |
• basolateral plasma membrane
|
| Biological process |
• transmembrane transport
|
| Sources: QuickGO |
|
| RNA expression pattern |
|---|
|
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[1]
OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.
Clinical significance
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[2] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[3]
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[3]
Substrates
Small molecules that are transported by SLCO1B3 include:[4]
See also
References
Further reading
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