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Stratum granulosum

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Title: Stratum granulosum  
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Subject: Stratum spinosum, Stratum lucidum, Integumentary system, Skin, Filaggrin
Collection: Skin Anatomy
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Stratum granulosum

Histologic image showing a section of epidermis. Stratum granulosum labeled near center.

The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis.[1] Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with histidine- and cystine-rich proteins that appear to bind the keratin filaments together. Therefore, the main function of keratohyalin granules is to bind intermediate keratin filaments together.[2][3]

At the transition between this layer and the corneocytes in the stratum corneum.[3]

Additional images

See also

References

  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 2. ISBN 0-7216-2921-0.
  2. ^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 7. ISBN 1-4160-3185-5.
  3. ^ a b Ovaere P, Lippens S, Vandenabeele P, Declercq W. (2009). "The emerging roles of serine protease cascades in the epidermis". Trends in Biochemical Sciences 34 (9): 453–463.  
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