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Sulfinpyrazone

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Title: Sulfinpyrazone  
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Subject: Uricosuric, Antigout agents, Ethenzamide, Amfenac, ATC code M04
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Sulfinpyrazone

Sulfinpyrazone
Systematic (IUPAC) name
1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
Clinical data
Trade names Apo-sulfinpyrazone
AHFS/Drugs.com
MedlinePlus
Legal status
?
Routes oral intravenous
Pharmacokinetic data
Protein binding 98–99%
Metabolism hepatic
Excretion renal
Identifiers
CAS number  YesY
ATC code M04
PubChem
DrugBank
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
ChEMBL  YesY
Chemical data
Formula C23H20N2O3S 
Mol. mass 404.48 g/mol
 YesY   

Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.

Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.

Contraindications

Sulfinpyrazone must not be used in persons with renal impairment or a high rate of excretion of uric acid (hyperuricosuria).[1]

Synthesis

References

  1. ^ Underwood M (June 2006). "Diagnosis and management of gout". BMJ 332 (7553): 1315–9.  


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