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Title: Suprofen  
Author: World Heritage Encyclopedia
Language: English
Subject: Felbinac, Janssen Pharmaceutica, Non-steroidal anti-inflammatory drugs, Ethenzamide, Amfenac
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
Clinical data
  • US: C (Risk not ruled out)
Legal status
  • Discontinued
Routes of
Oral, eye drops
Pharmacokinetic data
Protein binding 20%
CAS Registry Number  YesY
ATC code M01
PubChem CID:
DrugBank  YesY
ChemSpider  N
Chemical data
Formula C14H12O3S
Molecular mass 260.309 g/mol

Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.


Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]


  1. ^ DE 2353357 
  2. ^
  3. ^ Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
  4. ^ suprofen ophthalmic

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