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Tachykinin receptor

 

Tachykinin receptor

tachykinin receptor 1
Identifiers
Symbol TACR1
Alt. symbols TAC1R
Entrez 6869
HUGO 11526
OMIM 162323
RefSeq NM_001058
UniProt P25103
Other data
Locus Chr. 2 p13.1-p12
tachykinin receptor 2
Identifiers
Symbol TACR2
Alt. symbols TAC2R, NKNAR
Entrez 6865
HUGO 11527
OMIM 162321
RefSeq NM_001057
UniProt P21452
Other data
Locus Chr. 10 q11-q21
tachykinin receptor 3
Identifiers
Symbol TACR3
Entrez 6870
HUGO 11528
OMIM 162332
RefSeq NM_001059
UniProt P29371
Other data
Locus Chr. 4 q25

There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).

Contents

  • Binding 1
  • See also 2
  • References 3
  • External links 4

Binding

The genes and receptor ligands are as follows:[1]

Receptor Gene Preferred ligand
NK1 TACR1 substance P
NK2 TACR2 neurokinin A
NK3 TACR3 neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

References

  1. ^ Maggi CA (1995). "The mammalian tachykinin receptors". Gen. Pharmacol. 26 (5): 911–44.  

External links

  • "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • Tachykinin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)


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