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Title: Talsupram  
Author: World Heritage Encyclopedia
Language: English
Subject: Norepinephrine reuptake inhibitor
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • Uncontrolled
Routes Oral
CAS number
ATC code None
Chemical data
Formula C20H25NS 
Mol. mass 311.48 g/mol

Talsupram (Lu 5-005) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[1][2][3] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[4]

See also


  1. ^ Pawłowski L, Mazela H (1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology 88 (2): 240–6. PMID 3006113. doi:10.1007/BF00652248. 
  2. ^ McConathy J, Owens MJ, Kilts CD, et al. (August 2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology 31 (6): 705–18. PMID 15246361. doi:10.1016/j.nucmedbio.2003.05.001. 
  3. ^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology 28 (3): 332–47. PMID 12573300. doi:10.1016/S0306-4530(02)00026-4. 
  4. ^

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