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Thiobarbital

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Title: Thiobarbital  
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Subject: CGS-8216, CP-615,003, Heptobarbital, Nealbarbital, Probarbital
Collection: Gabaa Receptor Positive Allosteric Modulators, Thiobarbiturates
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Thiobarbital

Thiobarbital
Systematic (IUPAC) name
5,5-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
Pregnancy
category
  • ?
Legal status
  • ?
Routes of
administration
?
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Biological half-life ?
Excretion ?
Identifiers
CAS Registry Number  N
ATC code ?
PubChem CID:
DrugBank  N
ChemSpider  Y
Chemical data
Formula C8H12N2O2S
Molecular mass 200.259
 N   

Thiobarbital is a drug which is a barbiturate derivative. It is the thiobarbiturate analogue of barbital.

Synthesis

Thiobarbital synthesis:[1][2]

It is of note that although the drug can be prepared by the above route (cf eg thialbarbital), rxn of barbital with phosphorus pentasulfide constitutes an alternative route to thiobarbital.

References

  1. ^ Fischer, E.; Dilthey, A. (1904). "Ueber C-Dialkylbarbitursäuren und über die Ureïde der Dialkylessigsäuren". Justus Liebig's Annalen der Chemie 335 (3): 334.  
  2. ^ Carrington, H. C. (1944). "45. The action of phosphorus pentasulphide on barbituric acids". Journal of the Chemical Society (Resumed): 124.  


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