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Title: Ube2l6  
Author: World Heritage Encyclopedia
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Subject: Ubiquitin-conjugating enzyme, DNAJC13, DNAJB4, DNAJC10, DNAJC11
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Ubiquitin-conjugating enzyme E2L 6

PDB rendering based on 1wzv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; RIG-B; UBCH8
External IDs GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.[1][2] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]


  1. ^ Kumar S, Kao WH, Howley PM (Jul 1997). "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity". J Biol Chem 272 (21): 13548–54.  
  2. ^ a b "Entrez Gene: UBE2L6 ubiquitin-conjugating enzyme E2L 6". 

Further reading

  • Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.". J. Biol. Chem. 274 (13): 8570–6.  
  • Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.". J. Biol. Chem. 274 (43): 30963–8.  
  • Huang L, Kinnucan E, Wang G, et al. (1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.". Science 286 (5443): 1321–6.  
  • Nyman TA, Matikainen S, Sareneva T, et al. (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.". Eur. J. Biochem. 267 (13): 4011–9.  
  • Ardley HC, Rose SA, Tan N, et al. (2000). "Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12.". Cytogenet. Cell Genet. 89 (1–2): 137–40.  
  • Zhang Y, Gao J, Chung KK, et al. (2001). "Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13354–9.  
  • Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13.  
  • Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82.  
  • Urano T, Saito T, Tsukui T, et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature 417 (6891): 871–5.  
  • Chin LS, Vavalle JP, Li L (2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". J. Biol. Chem. 277 (38): 35071–9.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.  
  • Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502.  
  • Zhao C, Beaudenon SL, Kelley ML, et al. (2004). "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein". Proc. Natl. Acad. Sci. U.S.A. 101 (20): 7578–82.  
  • Tripathi MK, Chaudhuri G (2005). "Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells". Biochem. Biophys. Res. Commun. 328 (1): 43–8.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8.  
  • Li J, Wang J, Yang X, et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8". Mol. Cell. Biochem. 288 (1–2): 151–7.  
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