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Venom

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Venom

Venom is the toxin[1] used by venomous animals. Venom is injected into victims by means of a bite, sting or other sharp body feature.[2]

The potency of different venoms varies; lethal venoms are often characterised by the median lethal dose (LD50, LD50, or LD-50), expressed in terms of mass fraction (e.g., milligrams of toxin per kilogram of body mass), that will kill 50% of victims of a specified type (e.g., laboratory mice).

Utilization of venom across a large amount species demonstrates a classic example of convergent evolution and a homoplastic trait. It is difficult to conclude exactly how this trait came to be so intensely widespread and diversified. The multigene families that encode the toxins of venomous animals are actively selected on, creating more diverse toxins with specific functions. Venoms adapt to their environment and victims and accordingly evolve to become maximally efficient on a predator’s particular prey (particularly the precise ion channels within the prey). Consequently, venoms become specialized to an animal’s standard diet.[3]

Contents

  • Diversity 1
    • Invertebrates 1.1
    • Fish 1.2
    • Amphibians 1.3
    • Snakes 1.4
    • Other reptiles 1.5
    • Mammals 1.6
    • Therapsida 1.7
  • Treatment of venomous bites 2
  • See also 3
  • References 4
  • Bibliography 5

Diversity

Wasp sting, with a droplet of venom

Invertebrates

Venomous invertebrates include

evolution through gene duplications. Gene 496:1-7.

  • Wong, E. S., & Belov, K. (2012). Venom

M., Wong, E. S., Deakin, J. E., & Belov, K. (2008). Defensins and the convergent evolution of platypus and reptile venom genes.Genome research 18:986-994.

  • Whittington, C. M., Papenfuss, A. T., Bansal, P., Torres, A.

Venomous mammals: a review. Toxicon 59:680-695.

  • Ligabue-Braun, R., Verli, H., & Carlini, C. R. (2012).

animal toxin multigene families. Gene 261:43-52.

  • Kordiš, D., & Gubenšek, F. (2000). Adaptive evolution of

W., & Mulley, J. F. (2014). Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins.BioRxiv.

  • Fry, B. G., W. Wuster, S. F. R. Ramjan, T. Jackson, P. Martelli, and R. M. Kini. 2003c. Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: Evolutionary and toxinological implications. Rapid Communications in Mass Spectrometry 17:2047-2062.
  • Hargreaves, A. D., Swain, M. T., Hegarty, M. J., Logan, D.
  • Fry, B. G., S. Wroe, W. Teeuwisse, M. J. P. van Osch, K. Moreno, J. Ingle, C. McHenry, T. Ferrara, P. Clausen, H. Scheib, K. L. Winter, L. Greisman, K. Roelants, L. van der Weerd, C. J. Clemente, E. Giannakis, W. C. Hodgson, S. Luz, P. Martelli, K. Krishnasamy, E. Kochva, H. F. Kwok, D. Scanlon, J. Karas, D. M. Citron, E. J. C. Goldstein, J. E. Mcnaughtan, and J. A. Norman. 2009b. A central role for venom in predation by Varanus komodoensis (Komodo Dragon) and the extinct giant Varanus (Megalania) priscus" Proceedings of the National Academy of Sciences of the United States of America 106:8969-8974.
  • Fry, B. G., N. Vidal, J. A. Norman, F. J. Vonk, H. Scheib, S. F. R. Ramjan, S. Kuruppu, K. Fung, S. B. Hedges, M. K. Richardson, W. C. Hodgson, V. Ignjatovic, R. Summerhayes, and E. Kochva. 2006. Early evolution of the venom system in lizards and snakes. Nature (London) 439:584-588.
  • Lans C, Harper T, Georges K, Bridgewater E (2001). "Medicinal and ethnoveterinary remedies of hunters in Trinidad". BMC Complement Altern Med 1: 10.  
  • Smith WL, Wheeler WC (2006). "Venom evolution widespread in fishes: a phylogenetic road map for the bioprospecting of piscine venoms". J. Hered. 97 (3): 206–17.  

Bibliography

  1. ^ "venom" at Dorland's Medical Dictionary
  2. ^ "venom - Definition from the Merriam-Webster Online Dictionary". Retrieved 13 December 2008. 
  3. ^ Kordiš, D., & Gubenšek, F. (2000). Adaptive evolution of animal toxin multigene families. Gene 261:43-52.
  4. ^ Post, David; Robert Jeanne (1983). "Venom: Source of a Sex Pheromone in the Social Wasp Polistes fuscatus (Hymenoptera: Vespidae)". Journal of Chemical Ecology 9 (2): 259–266. doi:10.1007/bf00988043.
  5. ^ Post, Downing and Jeanne (1984). "Alarm response to venom by social wasps Polistes exclamans and P. fuscatus". Journal of Chemical Ecology 10 (10): 1425–1433. doi:10.1007/BF00990313.
  6. ^ Greene, Alex. "The Aerial Yellowjacket Dolichovespula Arenaria." Academia.edu. Department of Entomology - Washington State University, n.d. Web. 25 Sept. 2014.
  7. ^ Baracchi, David (January 2012). "From individual to collective immunity: The role of the venom as antimicrobial agent in the Stenogastrinae wasp societies". Journal of Insect Physiology. Retrieved 2014-11-15. 
  8. ^ Baptista-Saidemberg, Nicoli, et al. 2011. Profiling the peptidome of the venom from the social wasp Agelaia pallipes pallipes. Journal of Proteomics. 74(10): 2123-2137
  9. ^ Graystock, Peter; Hughes, William O. H. (2011). "Disease resistance in a weaver ant, Polyrhachis dives, and the role of antibiotic-producing glands". Behavioral Ecology and Sociobiology.  
  10. ^ Venomous Amphibians (Page 1) - Reptiles (Including Dinosaurs) and Amphibians - Ask a Biologist Q&A. Askabiologist.org.uk. Retrieved on 2013-07-17.
  11. ^ Nowak, R. T.; Brodie, E. D. (1978). "Rib Penetration and Associated Antipredator Adaptations in the Salamander Pleurodeles waltl (Salamandridae)". Copeia 1978 (3): 424–429.  
  12. ^ Hargreaves, A. D., Swain, M. T., Hegarty, M. J., Logan, D. W., & Mulley, J. F. (2014). Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins.BioRxiv.
  13. ^ Daltry, Jennifer C., Wolfgang Wuester, and Roger S. Thorpe. "Diet and snake venom evolution." Nature 379.6565 (1996): 537-540.
  14. ^ a b Fry BG, Wroe S, Teeuwisse W, et al. (June 2009). "priscus) Megalania (Varanus (Komodo Dragon) and the extinct giant Varanus komodoensis"A central role for venom in predation by . Proc. Natl. Acad. Sci. U.S.A. 106 (22): 8969–74.  
  15. ^ Fry, B. G., W. Wuster, S. F. R. Ramjan, T. Jackson, P. Martelli, and R. M. Kini. 2003c. Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: Evolutionary and toxinological implications. Rapid Communications in Mass Spectrometry 17:2047-2062.
  16. ^ Fry BG; Vidal N; Norman JA; Vonk FJ; Scheib H; Ramjan SF; Kuruppu S; Fung K; Hedges SB; Richardson MK; Hodgson WC; Ignjatovic V; Summerhayes R; Kochva E (February 2006). "Early evolution of the venom system in lizards and snakes" (PDF). Nature 439 (7076): 584–588.  
  17. ^ Ligabue-Braun, R., Verli, H., & Carlini, C. R. (2012). Venomous mammals: a review. Toxicon 59:680-695.
  18. ^ Wong, E. S., & Belov, K. (2012). Venom evolution through gene duplications. Gene 496:1-7.
  19. ^ Whittington, C. M., Papenfuss, A. T., Bansal, P., Torres, A. M., Wong, E. S., Deakin, J. E., & Belov, K. (2008). Defensins and the convergent evolution of platypus and reptile venom genes.Genome research 18:986-994.

References

See also

Aristolochia rugosa and Aristolochia trilobata, or "Dutchman's Pipe", are recorded in a list of plants used worldwide and in the West Indies, South and Central America against snakebites and scorpion stings. Aristolochic acid inhibits inflammation induced by immune complexes, and nonimmunological agents (carrageenan or croton oil). Aristolochic acid inhibits the activity of snake venom phospholipase (PLA2) by forming a 1:1 complex with the enzyme. Since phospholipase enzymes play a significant part in the cascade leading to the inflammatory and pain response, their inhibition could lead to relief of problems from scorpion envenomation.

Physicians treat victims of a venomous bite with antivenom, which is created by dosing an animal such as a sheep, horse, goat, or rabbit with a small amount of the targeted venom. The immune system of the subject animal responds to the dose, producing antibodies to the venom's active molecules; the antibodies can then be harvested from the animal's blood and injected into bite victims to treat envenomation. This treatment can be used effectively only a limited number of times for a given individual, however, as a bite victim will ultimately develop antibodies to neutralize the foreign animal antigens injected into them as components of the antivenin. This is called sensitization. Even if a bite victim does not suffer a serious allergic reaction to the antivenom, his own, sensitized, immune system may destroy the antivenom before the antivenom can destroy the venom. Though most individuals never require even one treatment of anti-venom in their lifetime, let alone several, those routinely exposed to snakes or other venomous animals may become sensitized to antivenom due to previous exposure.

Treatment of venomous bites

Euchambersia, a genus of therocephalians (animals close to the evolution of mammals) is known to have had venom glands attached to its canine teeth, used to help subdue and kill its prey. The potency of its venom is unknown.

Therapsida

Extensive research on platypuses shows that their toxin was initially formed from gene duplication, but data provides evidence that the further evolution of platypus venom does not rely as much on gene duplication as once was thought.[18] Modified sweat glands are what evolved into platypus venom glands. Although it is proven that reptile and platypus venom have independently evolved, it is thought that there are certain protein structures that are favored to evolve into toxic molecules. This provides more evidence as to why venom has become a homoplastic trait and why very different animals have convergently evolved.[19]

Some mammals are also venomous, including solenodons, shrews, and the male platypus. Shrews are known to have venomous saliva and most likely evolved their trait similarly to snakes.[17]

Mammals

Due to these recent studies investigating venom glands in squamates, lizards that were previously thought of as being nonvenomous are now being classified by some scientists as venomous because they possess a venom gland. This hypothetical clade, Toxicofera, includes all venomous squamates: the suborders Serpentes and Iguania and the families Varanidae, Anguidae, and Helodermatidae.[16]

One such reptile that was previously thought of as being nonvenomous is the Komodo dragon, Varanus komodoensis. It was then demonstrated through magnetic resonance imaging that the Komodo dragon possesses a mandibular gland with a major posterior compartment and five smaller anterior compartments.[14] The scientists used mass spectrometry to show that the mixture of proteins present in the venom was as complex as the proteins found in snake venom.[14][15]

Aside from snakes, venom is found in a few other reptiles such as the Mexican beaded lizard and gila monster, and may be present in a few species of monitor lizards.

Other reptiles

The composition of snake venom can vary within a species due to diet variation, which is caused by differences in geological location.[13]

Scientists believe the origin of snake venom began with gene duplication of genes that had been expressed in the body tissues of ancestors. Due to subfunctionalization, in which an ancestral function is split between the copied genes, one of the duplicates becomes limited to only the venom (salivary) gland and as a result, evolves in to the toxin producing gene. Data has shown that pre-existing proteins in the salivary glands were the origin of the toxins in snake venom. Some researchers have come to see snake venom as just “a modified form of saliva,” instead of an entirely recruited set of proteins from various tissues throughout the body.[12]

Snake venom is produced by glands below the eye (the mandibular gland) and delivered to the victim through tubular or channeled fangs. Snake venoms contain a variety of peptide toxins, including proteases, which hydrolyze protein peptide bonds, nucleases, which hydrolyze the phosphodiester bonds of DNA, and neurotoxins, which disable signalling in the nervous system. Snakes use their venom principally for hunting, though they do not hesitate to employ it defensively. Venomous snake bites may cause a variety of symptoms, including pain, swelling, tissue necrosis, low blood pressure, convulsions, hemorrhage (varying by species of snake), respiratory paralysis, kidney failure, coma and death.

The reptiles most known to use venom are snakes, some species of which inject venom into their prey via fangs.

Snakes

There are only a few known species of venomous amphibians; certain salamandrid salamanders can extrude sharp venom-tipped ribs.[10][11]

Amphibians

Venom can also be found in some fish, such as the cartilaginous fishes – stingrays, sharks, and chimaeras – and the teleost fishes including onejaws, catfishes, stonefishes and waspfishes, scorpionfishes and lionfishes, gurnards, rabbitfishes, dragonets, surgeonfishes, scats, stargazers, weever, and swarmfish.

Fish

There are many other venomous invertebrates, including jellyfish, cone snails and coleoids. The box jellyfish is the most venomous jellyfish in the world.

Bees synthesize and employ an acidic venom (apitoxin) to cause pain in those that they sting to defend their hives and food stores, whereas wasps use a chemically different alkaline venom designed to paralyze prey, so it can be stored alive in the food chambers of their young. The use of venom is much more widespread than just these examples. Other insects, such as true bugs and many ants, also produce venom. At least one ant species (Polyrhachis dives) has been shown to use venom topically for the sterilisation of pathogens.[9]

Many caterpillars have defensive venom glands associated with specialized bristles on the body, known as urticating hairs, which can be lethal to humans (e.g., that of the Lonomia moth), although the venom's strength varies depending on the species.

This prevents the spread of disease throughout the colony. [8]

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