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Vorozole

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Title: Vorozole  
Author: World Heritage Encyclopedia
Language: English
Subject: Medroxyprogesterone acetate, Cyproterone acetate, Antiestrogen, Quingestanol acetate, Estradiol enanthate
Collection: Aromatase Inhibitors, Benzotriazoles, Chloroarenes, Organochlorides, Triazoles
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Vorozole

Vorozole
Systematic (IUPAC) name
6-[(4-Chlorophenyl)(1,2,4-triazol-1-yl)methyl]-1-methylbenzotriazole
Pharmacokinetic data
Bioavailability Very high
Metabolism Hepatic
Biological half-life 8 hours
Identifiers
CAS Registry Number  N
ATC code L02
PubChem CID:
ChemSpider  Y
UNII  Y
KEGG  Y
ChEMBL  Y
Chemical data
Formula C16H13ClN6
Molecular mass 324.768 g/mol
 N   

Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.

It is selective.[1]

References

  1. ^ Goss PE (1998). "Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor" (PDF). Breast Cancer Res. Treat. 49. Suppl 1: S59–65; discussion S73–7.  



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