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William Jencks

William Platt Jencks
Born (1927-08-15)August 15, 1927
Bar Harbor, Maine
Died January 3, 2007(2007-01-03) (aged 79)
Nationality American
Fields Biochemistry
Institutions National Academy of Sciences
Brandeis University
Alma mater Harvard College

William Platt Jencks (August 15, 1927 – January 3, 2007) was an

  • National Academy of Sciences Biographical Memoir

External links

  1. ^ John Lowenstein (2007). "In Memoriam William Jencks". Retrieved 2008-08-04. 
  2. ^ Stu Borman (2007). "Enzymologist William Jencks Dies at 79". Retrieved 2008-08-04. 
  3. ^ a b c Jencks, W. P. (1997). "From Chemistry to Biochemistry to Catalysis to Movement". Annual Review of Biochemistry 66: 1–18.  
  4. ^ a b c Kirsch, J. F.; Richard, J. P. (2011). "William Platt Jencks. 15 August 1927 -- 3 January 2007".  
  5. ^ Jencks, W. P. (1981). "On the attribution and additivity of binding energies". Proceedings of the National Academy of Sciences of the United States of America 78 (7): 4046–4050.  
  6. ^ Jencks, William P. (1987). Catalysis in chemistry and enzymology. Mineola, N.Y: Dover.  
  7. ^ a b c Kirsch, Jack F.; John P. Richard (2010). "William Platt Jencks (1927–2007)". Biographical memoirs. Washington: National Academy of Sciences.  
  8. ^ Richard, John P.; Jack F. Kirsch (2009). "William Platt Jencks". Proceedings of the American Philosophical Society 153 (1): 97. 


  • Jencks, W. P. (1994). "Reaction mechanisms, catalysis, and movement". Protein Science 3 (12): 2459–2464.  
  • Jencks, William P. (1969). Catalysis in chemistry and enzymology. McGraw-Hill series in advanced chemistry. New York: McGraw-Hill. 

Selected bibliography

Jencks's father, Gardner Jencks, was a pianist and composer.[3] Jencks attended the Marine Biological Laboratory at Woods Hole on lobster shell pigments.[7] At Woods Hole, he met his future wife, Miriam Ehrlich. Jencks was survived by Miriam, his wife of 56 years, children Sara and David, grandson Benjamin, and siblings Charles Jencks (b. 1939) a landscape architect, Penelope Jencks-Hurwitz, and John Cheetham.

Personal life

Jencks was a recipient of the 1962 American Chemical Society Repligen Corporation Award in Chemistry of Biological Processes. He was elected to the National Academy of Sciences in 1971.[7] Jencks was also a foreign member of the Royal Society[4] and a member of the American Philosophical Society.[8]

Honors and awards

Jencks was a co-founder of the biannual Winter Enzyme Mechanisms Conference. He was memorialized at the 20th Enzyme Mechanisms Meeting in St. Pete Beach, Florida, several days after his death.

Much of his career focused on reaction mechanisms used by enzyme catalysts. He was particularly well known for studies of the reaction of nucleophiles with carbon. He proposed that enzymes use ground state destabilization, termed the Circe effect, to increase the reactivity of their bound substrates.[5] Many of these research interests were explored in his influential[4]:183 text Catalysis in Chemistry and Enzymology.[6] Jencks published close to 400 scientific papers during his career.[7]

Jencks graduated from Harvard College in 1947 with a degree in English, and earned an Doctor of Medicine from Harvard University in 1951.[4] He interned at the Peter Bent Brigham hospital. Jencks conducted his first postdoctoral research for two years with Fritz Lipmann at Harvard Medical School.[3] Jencks was drafted into the Army Medical Corps and was assigned to the Army Medical Service Graduate School at Walter Reed Medical Center in Washington, DC. He worked with E. L. Durrum and served as the chair of the department of pharmacology. In 1956–1957, he did a second Public Health Service postdoc with R. B. Woodward of the Harvard University Department of Chemistry. In 1957, he moved to the new graduate program in biochemistry at Brandeis University. He became professor emeritus in 1996.



  • Career 1
  • Honors and awards 2
  • Personal life 3
  • Selected bibliography 4
  • References 5
  • External links 6


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