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Title: Yangonin  
Author: World Heritage Encyclopedia
Language: English
Subject: Kava, Kavalactone
Publisher: World Heritage Encyclopedia


CAS number 500-62-9 YesY
PubChem 5281575
ChemSpider 4444896 N
Jmol-3D images Image 1
Molecular formula C15H14O4
Molar mass 258.27 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Yangonin is one of the six major kavalactones found in the kava plant.[1] It has been shown to possess significant binding affinity for the cannabinoid receptor CB1.[2] As this is the psychoactive cannabinoid receptor, yangonin may be responsible for some of kava's anxiolytic, analgesic, and intoxicating effects.

Medical use

The CB1 agonist activity of yangonin mimics most of the psychoactive effects of THC, including a reduction of anxiety, and possibly pain. This, along with the GABAergic effects of other kavalactones has given kava a use in the ethnobotanical treatment of anxiety, insomnia, pain, and other disorders.[3][4]


Yangonin displays marked in vitro toxicity on human hepatocytes with approximately 40% reduction in viability based on an ethidium bromide assay. The predominant mode of cell death turned out to be apoptosis rather than necrosis. No significant changes were observed in glutathione levels.[5]


See also

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