World Library  
Flag as Inappropriate
Email this Article

Zk-93423

Article Id: WHEBN0023442740
Reproduction Date:

Title: Zk-93423  
Author: World Heritage Encyclopedia
Language: English
Subject: Nonbenzodiazepine, CP-615,003, Heptobarbital, Nealbarbital, Lanthanum
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Zk-93423

ZK-93423
Systematic (IUPAC) name
ethyl 4-(methoxymethyl)-6-(phenylmethoxy) -9H-pyrido[5,4-b]indole-3-carboxylate
Clinical data
Legal status
  • legal
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  N
Chemical data
Formula C23H22N2O4 
Mol. mass 390.431 g/mol
 N   

ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil.[1] It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally.[2] It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs.[3][4][5][6] ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor.[7][8][9][10][11][12]

See also

References

  1. ^ Zhang H, Larock RC (December 2002). "Synthesis of beta- and gamma-carbolines by the palladium-catalyzed iminoannulation of alkynes". The Journal of Organic Chemistry 67 (26): 9318–30.  
  2. ^ Stephens DN, Shearman GT, Kehr W (1984). "Discriminative stimulus properties of beta-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors". Psychopharmacology 83 (3): 233–9.  
  3. ^ Klockgether T, Pardowitz I, Schwarz M, Sontag KH, Turski L (October 1985). "Evaluation of the muscle relaxant properties of a novel beta-carboline, ZK 93423 in rats and cats".  
  4. ^ Cooper SJ (January 1986). "Hyperphagic and anorectic effects of beta-carbolines in a palatable food consumption test: comparisons with triazolam and quazepam". European Journal of Pharmacology 120 (3): 257–65.  
  5. ^ File SE, Baldwin HA (September 1987). "Effects of beta-carbolines in animal models of anxiety". Brain Research Bulletin 19 (3): 293–9.  
  6. ^ Löscher W, Hönack D, Hashem A (November 1987). "Anticonvulsant efficacy of clonazepam and the beta-carboline ZK 93423 during chronic treatment in amygdala-kindled rats". European Journal of Pharmacology 143 (3): 403–14.  
  7. ^ Dodd RH, Ouannès C, Potier MC, Prado de Carvalho L, Rossier J, Potier P (July 1987). "Synthesis of beta-carboline-benzodiazepine hybrid molecules: use of the known structural requirements for benzodiazepine and beta-carboline binding in designing a novel, high-affinity ligand for the benzodiazepine receptor". Journal of Medicinal Chemistry 30 (7): 1248–54.  
  8. ^ Hollinshead SP, Trudell ML, Skolnick P, Cook JM (March 1990). "Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester". Journal of Medicinal Chemistry 33 (3): 1062–9.  
  9. ^ Diaz-Arauzo H, Evoniuk GE, Skolnick P, Cook JM (May 1991). "The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic". Journal of Medicinal Chemistry 34 (5): 1754–6.  
  10. ^ Sharma RC, Ojha TN, Tiwari S, Singh P (1992). "Quantitative structure-activity relationship study of some benzodiazepine-receptor ligands having inverse agonist/antagonist and agonist actions". Drug Design and Discovery 9 (2): 135–43.  
  11. ^ Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM (July 1998). "Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors". Journal of Medicinal Chemistry 41 (14): 2537–52.  
  12. ^ Ferretti V, Gilli P, Borea PA (August 2004). "Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor". Acta Crystallographica B 60 (Pt 4): 481–9.  


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.