Environmental Health Perspectives, Vol. 76, Pp. 71-77, 1987 : Ah Receptor : Relevance of Mechanistic Studies to Human Risk Assessment

By Cook, Jon C.

Book Id: WPLBN0000004939
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Reproduction Date: 2005

Title:	Environmental Health Perspectives, Vol. 76, Pp. 71-77, 1987 : Ah Receptor : Relevance of Mechanistic Studies to Human Risk Assessment
Author:	Cook, Jon C.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago C. Coo, B. J. (n.d.). Environmental Health Perspectives, Vol. 76, Pp. 71-77, 1987 : Ah Receptor : Relevance of Mechanistic Studies to Human Risk Assessment. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the extensively studied prototype for the halogenated aromatic compounds (HACs), a large group of environmental toxicants that includes the dibenzo-p-dioxins, dibenzofurans, biphenyls, and azo- and azoxyhenzenes (1-3). Studies in various animal models and in human and animal cells in culture indicate that TCDD and isosteric HACs produce a characteristic pattern of pathologic lesions separable into two major categories: those that are widelv exuressed such as thvmic atrouhv, teratogenesis, a& wasting; and species:specific responses including hepatotoxicity, edema of the pericardium, and hyperkeratosis and chloracne (4). Hyperkeratosis and chloracne are responses commonly observed in humans (5,6). Other reported clinical abnormalities include weight loss, impaired liver function, hepatic porphyria, general malaise, and peripheral neuropathies (7). Suppression of specific T-lymphocyte functions has been reported in individuals who ingested PCB-contaminated rice oil (8-10). Chlorinated dibenzofurans present in the PCB mixture are the suspected immunoregressive agents (8-11).