Chemical and Biochemical Dosimetry Of-Exposure to Genotoxic Chemicals

By Wogan, Gerald N.

Book Id: WPLBN0000032007
Format Type: PDF eBook:
File Size: 1.10 MB
Reproduction Date: 2005

Title:	Chemical and Biochemical Dosimetry Of-Exposure to Genotoxic Chemicals
Author:	Wogan, Gerald N.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago N. Woga, B. G. (n.d.). Chemical and Biochemical Dosimetry Of-Exposure to Genotoxic Chemicals. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Two categorical types of measurements can be made in biological monitoring: measurements of levels of chemicals, their metabolites and/or derivatives in body fluids or excreta and measurements of biological responses such as mutation, sister chromatid exchange, chromosome aberrations, etc., in cells and tissues of exposed individuals. Quantification of chemicals in body fluids (e.g., blood, breast milk, saliva, semen) or in excreta has been carried out by direct chemical analysis, immunologic analysis, or can be inferred from results of bioassays for mutagenicity. Most of the existing chemical methods and available data relate to occupational exposure, since such measurements have been used in occupational hygiene programs for many years. Immunoassays and bioassays are more recent developments that have as yet found only limited application. With the recognition that most genotoxic chemicals require metabolic activation to electrophilic forms in order to express their effects, an additional strategy for chemical dosimetry has developed based upon the detection and quantification of covalently bound derivatives formed between activated chemicals and cellular macromolecules such as nucleic acids and proteins. Immunologic and chemical.