Testicular Effects of Phthalate Esters

By Gangolli, S. D.

Book Id: WPLBN0000050500
Format Type: PDF eBook:
File Size: 0.9 MB
Reproduction Date: 2005

Title:	Testicular Effects of Phthalate Esters
Author:	Gangolli, S. D.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago D. Gangoll, B. S. (n.d.). Testicular Effects of Phthalate Esters. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: This paper presents a brief review of some of the earlier work on phthalate-induced testicular injury followed by the results of studies conducted at BIBRA. The f i s t reported finding of phthalate-induced testicular injury in experimental animals was by Shaffer et al. (I) in 1945. The oral administration of di(2-ethylhexyl) phthalate (DEHP) at dietary concentrations of 0.075, 0.75, 1.5 and 5.0% to rats for 90 days resulted in tubular atrophy and testicular degeneration resembling senile changes at the two top dose levels. Subsequently, Harris et al. (2) found occasional incidence of tubular atrophy in rats fed DEHP at 0.5% in the diet for periods of 3 or 24 months.