Metal Composition of Ambient Pm2.5 Influences Severity of Allergic Airways Disease in Mice

By Gavett, Stephen H.

Book Id: WPLBN0000052878
Format Type: PDF eBook:
File Size: 0.2 MB
Reproduction Date: 2005

Title:	Metal Composition of Ambient Pm2.5 Influences Severity of Allergic Airways Disease in Mice
Author:	Gavett, Stephen H.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago H. Gavet, B. S. (n.d.). Metal Composition of Ambient Pm2.5 Influences Severity of Allergic Airways Disease in Mice. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Children living in Hettstedt in eastern Germany have been reported to have a higher prevalence of sensitization to common aeroallergens than another cohort living in the neighboring city of Zerbst; these differences correlated with the presence of industrial air pollution. Samples of fine particulate matter (< 2.5 micrometer aerodynamic diameter; PM2.5) collected in Hettstedt in 1999 had several-fold higher levels of zinc, magnesium, lead, copper, and cadmium than samples from Zerbst. To determine if the results from epidemiologic studies could be repeated in an animal model, we administered PM2.5 from Hettstedt and Zerbst to ovalbumin-allergic mice. In Balb/c mice, PM2.5 from Hettstedt, but not PM2.5 from Zerbst or control filter extract, caused a significant increase in immediate responses to ovalbumin challenge when aspirated 2 hr before challenge, but not when aspirated immediately before sensitization 2 weeks earlier. Antigen-specific IgE was increased by Hettstedt PM2.5 whether administered before sensitization or challenge. Airway responsiveness to methacholine aerosol and lung inflammatory cell numbers were significantly increased only in allergic mice exposed to Hettstedt PM2.5 before challenge. Both Hettstedt and Zerbst PM2.5 significantly increased lung injury parameters and proinflammatory cytokines. These results are consistent with epidemiologic findings and show that metal composition of ambient PM2.5 influences the severity of allergic respiratory disease. Key words: air pollution, airway hyperresponsiveness, allergic sensitization, asthma, epidemiology, inflammation, metals.