Nearest Neighbor Affects G:C to A:T Transitions Induced by Alkylating Agents

By Glickman, Barry W.

Book Id: WPLBN0000054967
Format Type: PDF eBook:
File Size: 0.2 MB
Reproduction Date: 2005

Title:	Nearest Neighbor Affects G:C to A:T Transitions Induced by Alkylating Agents
Author:	Glickman, Barry W.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago W. Glickma, B. B. (n.d.). Nearest Neighbor Affects G:C to A:T Transitions Induced by Alkylating Agents. Retrieved from https://self.gutenberg.org/

Description
Government Reference Publication

Excerpt
Excerpt: Alkylating agents represent a major class of potential human mutagens and carcinogens. These agents give rise to a large number of DNA adducts, both in vivo and in vitro (1,Z). The major adducts suspected of being responsible for the mutational and carcinogenic effects of these agents are the 0alkylguanine and the O4- alkylthymine adduct. Evidence indicating the potency of these adducts is derived from a number of sources. These include the observation that persistence and/or existence of adducts generally correlates with carcinogenesis in the target organs (3-5). Furthermore, these adducts have been shown to mispair in i v vit ro systems (6-8). In addition, 06-methylguanine and O4-methylthymine have been shown to mispair with thymine and guanine, respectively, in semi- in vivo site-specific mutational systems (9-11). Hence, there would appear to be more than adequate evidence indicating a role for these adducts in alkylation-induced mutagenesis.